Evidence map›Paper›PMID 36058924›Full record

ArticleJournal of translational medicine2022

Effects of a 4400 km ultra-cycling non-competitive race and related training on body composition and circulating progenitors differentiation.

Maria Teresa Valenti, Michele Braggio, Arianna Minoia, Gianluigi Dorelli, Jessica Bertacco, Francesco Bertoldo, Mattia Cominacini, Tonia De Simone, Maria Grazia Romanelli, Lekhana Bhandary and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maria Teresa ValentiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100, Verona, Italy.
Michele BraggioDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Arianna MinoiaDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Gianluigi DorelliDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Jessica BertaccoDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Francesco BertoldoDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Mattia CominaciniDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy.
Tonia De SimoneDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100, Verona, Italy.
Maria Grazia RomanelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100, Verona, Italy.
Lekhana BhandaryFlaskworks, LLC, 38 Wareham St, Boston, MA, 02118, USA.
Monica MottesDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100, Verona, Italy.
Luca Dalle CarbonareDepartment of Medicine, Section of Internal Medicine, University of Verona, Piazzale Scuro, 10, Policlinico G.B. Rossi, 37134, Verona, Italy. luca.dallecarbonare@univr.it.ORCID 0000-0003-3263-6671
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated: (a) before starting the preparation period; (b) in the week preceding NC4000 (after the training period); (c) after NC4000 race, with the aim to identify the effects of ultra-cycling on body composition, aerobic capacity and biochemical parameters as well as on the differentiation of progenitor cells.

methodsBioelectrical impedance analysis (BIA) and dual energy x-ray absorptiometry (DEXA) assessed body composition; cardiopulmonary exercise test (CPET) evaluated aerobic capacity. Differentiation of circulating progenitor cells was evaluated by analyzing the modulation in the expression of relevant transcription factors. In addition, in vitro experiments were performed to investigate the effects of sera of NC4000 participants on adipogenesis and myogenesis. The effects of NC4000 sera on Sestrins and Sirtuin modulation and the promotion of brown adipogenesis in progenitor cells was investigated as well. Two-tailed Student's paired-test was used to perform statistical analyses.

resultsWe observed fat mass decrease after training as well as after NC4000 performance; we also recorded that vitamin D and lipid profiles were affected by ultra-cycling. In addition, our findings demonstrated that post-NC4000 participant's pooled sera exerted a positive effect in stimulating myogenesis and in inducing brown adipogenesis in progenitor cells.

conclusionsThe training program and Ultra-cycling lead to beneficial effects on body composition and biochemical lipid parameters, as well as changes in differentiation of progenitor cells, with significant increases in brown adipogenesis and in MYOD levels.

Indexed as

Body CompositionLipidsAbsorptiometry, PhotonElectric ImpedanceHumansMaleLipidsAerobic capacityBiochemical parametersBody compositionFat massProgenitor cellsTrainingTranscription factorsUltra-cycling

Identifiers

PMID36058924
PMCPMC9441096
OpenAlexW4294668629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.