ArticleJournal of cachexia, sarcopenia and muscle2022
Sarcopenia and mild cognitive impairment among elderly adults: The first longitudinal evidence from CHARLS.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 4 of them syntheses that pooled it.
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Who cites it
220 citing papers in PubMed, 4 syntheses or guidelines pooled it, 301 citations in OpenAlex.
- The association of sarcopenia, possible sarcopenia and cognitive impairment: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Meta-analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.PloS one · 2024Pooled it
- Frontiers and hotspots evolution in mild cognitive impairment: a bibliometric analysis of from 2013 to 2023.Frontiers in neuroscience · 2024Pooled it
- The multiple composite risk index estimates the risks of sarcopenia and comorbidities: unveiling the role of oxidative balance score.Annals of medicine · 2026Article
- Possible Sarcopenia and Subsequent Cognitive Function in Older Chinese Adults: Limited Evidence for Mediation by Frailty.Geriatrics & gerontology international · 2026Observational
- Prevalence and Risk of Mild Cognitive Impairment Among Chinese Adults Aged 60 Years and Above: A Cross-Sectional Study Based on National Data.Actas espanolas de psiquiatria · 2026Article
- Associations between hearing and vision impairment and type 2 diabetes among middle-aged and older chinese adults: a nationwide longitudinal cohort study.Journal of health, population, and nutrition · 2026Observational
- Association of sarcopenic obesity with advanced cardiovascular-kidney-metabolic syndrome and incident cardiovascular disease: a longitudinal and cross-sectional study.Diabetology & metabolic syndrome · 2026Article
- Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults.GeroScience · 2026Article
- Mind, Mood, and Mobility: Rethinking Functional Disability Prevention in Older Adults on the Basis of a Longitudinal Cohort From CHARLS.Journal of the American Heart Association · 2026Article
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway.Journal of advanced research · 2026Article
- Amino acid and appendicular skeletal muscle mass insufficiency are associated to cognitive decline in Chinese population.GeroScience · 2026Article
- Longitudinal association between sarcopenia and comorbidity of mild cognitive impairment and depression among older adults in China: the moderating effect of non-obesity.BMC geriatrics · 2026Article
- Association between headache and hearing impairment in middle-aged and older adults in China health and retirement longitudinal study.Scientific reports · 2026Article
- Sustained moderate to high triglyceride-glucose index level is associated with a lower risk of sarcopenia in middle-aged and elderly adults: a nationally representative cohort study.Lipids in health and disease · 2026Article
- Sleep patterns and impaired cognitive function in adults aged ≥ 55 years: a longitudinal study in China.BMC public health · 2026Article
- Association of social isolation and loneliness with incident cardiovascular diseases: results from a nationally prospective cohorts in China.Social psychiatry and psychiatric epidemiology · 2026Article
- Altered Neuromuscular Control and Beta-Band Cortical Compensation During Gait in Sarcopenia: An Exploratory Study.Bioengineering (Basel, Switzerland) · 2026Article
160 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between sarcopenia and mild cognitive impairment (MCI) among elderly adults in China remains unclear. The present study aimed to examine the association based on a nationally representative large-scale survey.
methodsThe study used two waves of data from China Health and Retirement Longitudinal Study (CHARLS) in 2015 and 2018. All subjects met the inclusion criteria were classified based on Asia Working Group for Sarcopenia 2019 criteria. Aging-associated cognitive decline is used to define MCI, and cognitive function is measured based on four dimensions: orientation, computation, memory, and drawing. OLS and logistic regression model were conducted to analyse the cross-sectional association between sarcopenia and different cognitive functions. Logistic regression model was conducted to analyse the longitudinal association between sarcopenia and MCI.
resultsTotally, 5715 participants aged over 60 years (43.8% women; mean age 67.3 ± 6.0 years) were enrolled in a cross-sectional association study in 2015, and further 2982 elderly adults were followed up in 2018. During the period, sarcopenia and possible sarcopenia increased from 8.5% to 29.6%. Scores of cognitive and four dimensions (orientation, computation, memory, and drawing) exhibited a decreasing trend from non-sarcopenia to sarcopenia (P < 0.001). In the fully adjusted OLS regression model, scores of four dimensions were lower in possible sarcopenia and sarcopenia groups when compared with the non-sarcopenia group (P < 0.05) respectively. The incidence of MCI was 10.1%, 16.5%, and 24.2% for non-sarcopenia, possible sarcopenia, and sarcopenia groups from 2015 to 2018, with a significantly statistical difference (P < 0.001). Logistic regression model revealed an odds ratio of 1.43 [95% confidence interval (CI): 1.06-1.91, P = 0.017] for the possible sarcopenia group and 1.72 (95% CI: 1.04-2.85, P = 0.035) for sarcopenia group when compared with the non-sarcopenia group.
conclusionsSarcopenia is associated with worse cognitive impairment, which provided new evidence for a strong association that warrants further research into mechanistic insights.
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