Evidence map›Paper›PMID 36058518›Full record

ReviewAmerican journal of obstetrics & gynecology MFM2023

Postpartum hemorrhage protocols and benchmarks: improving care through standardization.

Jerome J Federspiel, Ahizechukwu C Eke, Catherine S Eppes

Registry-linked trialAbstract readReview
In one paragraph

Review in American journal of obstetrics & gynecology MFM, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07188207 (The Efficacy of Adding Preoperative Rectal Misoprostol for Decreasing Intraoperative and Postoperative Blood Loss at Elective Cesarean Section), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07188207 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy of Adding Preoperative Rectal Misoprostol for Decreasing Intraoperative and Postoperative Blood Loss at Elective Cesarean Section

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled282ConditionsPostpartum HemorrhageArmsOxytocin
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
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  4. Review
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  8. Observational
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  16. Maternal and Neonatal Outcomes of Adolescent Pregnancy in Vietnam.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2024
    Article
  17. Article
  18. Multidisciplinary team training in postpartum hemorrhage: impact on the use of blood products.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jerome J FederspielFrom the Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC (Dr Federspiel). Electronic address: jjf7@duke.edu.
Ahizechukwu C EkeDivision of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD (Dr Eke); Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD (Dr Eke).
Catherine S EppesDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX (Dr Eppes).

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
NRSA Training CoreTL1TR002555 · NCATS · DUKE UNIVERSITY · PI EDELMAN, DAVID · 2018 to 2022
$3.7M
Understanding Medication Adherence Benchmarks, Safety and Pharmacometrics of Novel Antiretrovirals in Pregnant Women Living with HIV.K23HD104517 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EKE, AHIZECHUKWU C. · 2020 to 2024
$857k
NCATS NIH HHS TL1 TR002555NCATS NIH HHS UL1 TR002553NICHD NIH HHS K23 HD104517
6 · The paper itself

Abstract

Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality in the United States. Several state maternal morbidity and mortality committees have reviewed areas of opportunity concerning postpartum hemorrhage management and found that common patterns include delays in recognition and response to hemorrhage. Hospital systems and state perinatal quality collaboratives have found that comprehensive, interdisciplinary response to postpartum hemorrhage care improves patient outcomes and, in some instances, reduces racial disparities. A key component of this focus involves the implementation of stage-based hemorrhage protocols for postpartum hemorrhage management. Stage-based hemorrhage protocols are designed to reduce delays in the diagnosis and management and avoid the pitfalls of cognitive biases. These protocols are complex, and their effectiveness is tied to the quality of their implementation. Systematic benchmarking and development of quality metrics for adherence to postpartum hemorrhage bundles would be expected to improve clinical outcomes, but evidence regarding the effectiveness of this practice in the literature is limited. Here, key features of stage-based interventions and evidence regarding the use of quality metrics for postpartum hemorrhage protocol adherence have been outlined.

Indexed as

Postpartum HemorrhageBenchmarkingFemaleHospitalsHumansPregnancyQuality ImprovementReference StandardsUnited Statesmaternal deathobstetrical labor complicationspostpartum hemorrhagepregnancyquality improvement

Identifiers

PMID36058518
PMCPMC9941009

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.