Evidence map›Paper›PMID 36058012›Full record

ArticleThe Journal of surgical research2022

A Propensity-Matched Analysis of Tranexamic Acid and Acute Respiratory Distress Syndrome in Trauma Patients.

Sharven Taghavi, Tristan Chun, Lillian Bellfi, Catherine Malone, Jadesola Oremosu, Ayman Ali, Eman Toraih, Juan Duchesne, Danielle Tatum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sharven TaghaviTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana. Electronic address: staghavi@tulane.edu.
Tristan ChunTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Lillian BellfiUniveristy Medical Center, Trauma Critical Care, New Orleans, Louisiana.
Catherine MaloneTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Jadesola OremosuTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Ayman AliTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Eman ToraihTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Juan DuchesneTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Danielle TatumTulane University School of Medicine, Department of Surgery, Division of Trauma and Critical Care, New Orleans, Louisiana.
Tulane University · USUniversity Medical Center New Orleans · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Daniel F Sarpong · 2012 to 2026
$69.1M
Center for Youth Equity (CYE) at Tulane University: A Community-Centered Approach to Youth Violence PreventionU01CE003384 · CE · TULANE UNIVERSITY OF LOUISIANA · PI CONSTANS, JOSEPH I, THEALL, KATHERINE P · 2021 to 2025
$4.7M
NCIPC CDC HHS U01 CE003384NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

introductionTranexamic acid (TXA) protects the vasculature endothelium after hemorrhage, resulting in a decreased capillary leak. These properties may protect patients receiving TXA from acute respiratory distress syndrome (ARDS), however, clinical studies have yet to examine this topic. We hypothesized that trauma patients receiving TXA would have lower incidence of ARDS.

methodsThis was a retrospective review of adult (18+ y) patients who presented to a large Level I trauma center with an injury severity score ≥ 16 from admit years 2012-2020. Propensity matching was employed to examine how TXA administration is associated with ARDS.

resultsThere were a total of 2751 patients meeting study criteria, with 162 (5.9%) received TXA. Of the 162 patients that received TXA, only 12 (7.4%) received pre-hospital TXA, while 4 (2.5%) received TXA both pre-hospital and in hospital. Of the 63 patients developing ARDS, 62 (98.4%) did not receive TXA. After propensity matching, 304 patients remained, with 152 in each cohort. The incidence of ARDS (P = 0.08), pneumonia (P = 0.68), any pulmonary complication (P = 0.33), and mortality (P = 0.37) were not different in patients receiving TXA on propensity matching.

conclusionsTXA did not protect trauma patients from pulmonary complications; however, nearly all patients developing ARDS did not receive TXA. Larger studies should examine this relationship to improve understanding of therapies that may prevent ARDS.

Indexed as

Antifibrinolytic AgentsRespiratory Distress SyndromeTranexamic AcidAdultHumansInjury Severity ScoreTrauma CentersAntifibrinolytic AgentsTranexamic AcidAcute lung injuryAcute respiratory distress syndromePneumoniaTranexamic acid

Identifiers

PMID36058012
PMCPMC9575143
OpenAlexW4294250359

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.