Evidence map›Paper›PMID 36058009›Full record

ReviewCurrent opinion in neurobiology2022

Dopamine and norepinephrine are embracing their immune side and so should we.

Peter J Gaskill, Habibeh Khoshbouei

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026
    Article
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Peter J GaskillDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: pjg63@drexel.edu.
Habibeh KhoshboueiDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, USA. Electronic address: https://twitter.com/Khoshbouei_lab.
Drexel University · USTwitter (United States) · US

Funding

Alpha-synuclein Regulates Dopamine Transporter FunctionsR01NS071122 · NINDS · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2022
$3.9M
Methamphetamine regulates the dopamine transporter via an intracellular mechanismR01DA026947 · NIDA · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2019
$3.5M
Mechanisms of dopamine mediated increase in HIV infection of macrophagesR01DA039005 · NIDA · DREXEL UNIVERSITY · PI GASKILL, PETER JESSE · 2015 to 2019
$1.9M
DAT-Psychostimulant mediated dopamine release increases macrophage IL-1beta production through NF-kB activation and inflammasome primingR21DA049227 · NIDA · DREXEL UNIVERSITY · PI GASKILL, PETER JESSE · 2020 to 2021
$430k
Interactions between microglia and dopaminergic neurons regulates dopamine neurotransmissionR21DA043895 · NIDA · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH, STREIT, WOLFGANG J · 2017 to 2018
$415k
NIDA NIH HHS R01 DA026947NIDA NIH HHS R01 DA039005NIDA NIH HHS R21 DA043895NIDA NIH HHS R21 DA049227NINDS NIH HHS R01 NS071122
6 · The paper itself

Abstract

While the history of neuroimmunology is long, the explicit study of neuroimmune communication, and particularly the role of catecholamines in neuroimmunity, is still emerging. Recent studies have shown that catecholamines, norepinephrine, epinephrine, and dopamine, are central to multiple complex mechanisms regulating immune function. These studies show that catecholamines can be released from both the nervous system and directly from immune cells, mediating both autocrine and paracrine signaling. This commentary highlights the importance of catecholaminergic immunomodulation and discusses new considerations needed to study the role of catecholamines in immune homeostasis to best leverage their contribution to disease processes for the development of new therapeutic approaches.

Indexed as

DopamineNorepinephrineCatecholaminesEpinephrineNeuroimmunomodulationCatecholaminesDopamineEpinephrineNorepinephrine

Identifiers

PMID36058009
PMCPMC10481402
OpenAlexW4294232806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.