Evidence map›Paper›PMID 36057999›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Engineering Alendronate-Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment.

Jing Zhao, Xiuyu Huang, Peng Liu, Miaojuan Qiu, Binbin Li, Yingfei Wen, Yongshu Li, Qiang Wang, Meiying Wu, Yu Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jing ZhaoPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Xiuyu HuangPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Peng LiuPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Miaojuan QiuPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Binbin LiPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Yingfei WenPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Yongshu LiPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Qiang WangPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Meiying WuSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, P. R. China.ORCID 0000-0003-2664-0498
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Yihang PanPrecision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Sun Yat-sen University · CNShanghai University · CN

Funding

100 Top Talents Program of Sun Yat-sen University ZSQYBRJH0001Basic Research Program of Shanghai Municipal Government 21JC1406002Guangdong Provincial Key Laboratory of Digestive Cancer Research 2021B1212040006International Collaboration Project of Chinese Academy of Sciences GJHZ2072National Key Research and Development Program of China 2018YFA0902801National Natural Science Foundation of China 81902426National Natural Science Foundation of China 81971737Science and Technology Planning Project of Shenzhen Municipality JCYJ20210324122612032Science and Technology Planning Project of Shenzhen Municipality SGLH20181109105202075Technology Program 21010500100
6 · The paper itself

Abstract

Iron is an essential element for various cellular metabolism. Cancer cells also have high requirement of iron in their proliferation, invasion, and metastasis processes. Alendronate (ALN), a kind of FDA-approved bisphosphonates with metal-chelating capability, is initially certified to selectively bind to intracellular Fe

Indexed as

Peritoneal NeoplasmsAlendronateAnimalsCell Line, TumorHumansIronIron Chelating AgentsMiceReactive Oxygen SpeciesAlendronateIronIron Chelating AgentsReactive Oxygen Speciescalcium overloadchemotherapyinfinite coordination polymersiron chelatorovarian cancer

Identifiers

PMID36057999
PMCPMC9596851
OpenAlexW4294562710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.