SynthesisSports medicine - open2022
Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials.
Synthesis in Sports medicine - open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
- Pooled it
- Peri-operative protein or amino acid supplementation for total joint arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Effects of milk fat globule membrane ingestion with exercise on physical strength in healthy young adults: a randomized double-blind, placebo-controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Correlation between physiological and biochemical variables during short term adequate protein intake combined with resistance exercise in sedentary adults.Scientific reports · 2025Trial
- Effect of resistance training and chicken meat on muscle strength and mass and the gut microbiome of older women: A randomized controlled trial.Physiological reports · 2024Trial
- Increased physical performance after personalised physiotherapy and nutritional counselling in adults with post-COVID-19 condition: a feasibility randomised trial.Communications medicine · 2026Article
- No Differences in Muscular Adaptations to Long-Term Resistance Training Between Young Strict Vegetarian and Non-Vegetarian Women.Scandinavian journal of medicine & science in sports · 2026Article
- Pharmacologic treatment of obesity in adults: Standards of care in overweight and obesity.BMJ open diabetes research & care · 2026Review
- The effects of fitness self-testing with instant feedback on changes in health-related fitness among Chinese male college students.PloS one · 2026Article
- Performance Optimization in Streetlifting: The Combined Role of Nutrition, Lean Mass, and Sleep.Nutrients · 2025Review
- Article
- Cumulative handgrip strength and trajectories of depressive symptoms in older adults: evidence from two cohort studies.BMC public health · 2025Article
- Relationship between dietary protein and amino acid intake and handgrip strength in Korean adults: data from the 2014-2019 Korea National Health and Nutrition Examination Survey.Nutrition journal · 2025Article
- Request for Study Design Modification in Examining Nutritional Intake and Muscle Strength in Individuals with Airflow Limitation.Tuberculosis and respiratory diseases · 2025Article
- Assessment of body composition, sarcopenia and protein intake in mild to moderate Parkinson's disease.Frontiers in nutrition · 2025Article
- The effect of resistance training on physical function is associated with changes in serum albumin redox state in middle-aged and older Japanese adults: a Quasi-experimental study.Frontiers in physiology · 2025Article
- Omega-3 Fatty Acids and Muscle Strength-Current State of Knowledge and Future Perspectives.Nutrients · 2024Review
- Nutrition Practices of Lithuanian Elite International and National-level Male Bodybuilders in the Pre-competition Period.Journal of musculoskeletal & neuronal interactions · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProtein supplementation augments muscle strength gain during resistance training. Although some studies focus on the dose-response relationship of total protein intake to muscle mass or strength, the detailed dose-response relationship between total protein intake and muscle strength increase is yet to be clarified, especially in the absence of resistance training.
objectiveWe aimed to assess the detailed dose-response relationship between protein supplementation and muscle strength, with and without resistance training.
designSystematic review with meta-analysis. DATA SOURCES: PubMed and Ichushi-Web (last accessed on March 23, 2022). ELIGIBILITY CRITERIA: Randomized controlled trials investigating the effects of protein intake on muscle strength. SYNTHESIS
methodsA random-effects model and a spline model.
resultsA total of 82 articles were obtained for meta-analyses, and data from 69 articles were used to create spline curves. Muscle strength increase was significantly augmented only with resistance training (MD 2.01%, 95% CI 1.09-2.93) and was not augmented if resistance training was absent (MD 0.13%, 95% CI - 1.53 to 1.79). In the dose-response analysis using a spline model, muscle strength increase with resistance training showed a dose-dependent positive association with total protein intake, which is 0.72% (95% CI 0.40-1.04%) increase in muscle strength per 0.1 g/kg body weight [BW]/d increase in total protein intake up to 1.5 g/kg BW/d, but no further gains were observed thereafter.
conclusionConcurrent use of resistance training is essential for protein supplementation to improve muscle strength. This study indicates that 1.5 g/kg BW/d may be the most appropriate amount of total protein intake for maintaining and augmenting muscle strength along with resistance training.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.