ArticleNature communications2022
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Chemoenzymatic Synthesis of (4R,7R)-Zingiberene Enables Construction of nor-Sesquiterpene Semiochemical Analogs.Chembiochem : a European journal of chemical biology · 2026Article
- Revolutionizing drug discovery from natural products: The roles of artificial intelligence and multi-omics in accelerating innovation.Acta pharmaceutica Sinica. B · 2026Article
- Effects of 5 aminolevulinic acid on fruit quality and volatile metabolites of Meizao sweet cherry.Scientific reports · 2026Article
- Discovery and Biosynthesis of Farnesyl Pyrophosphate-Derived Noncanonical CJournal of the American Chemical Society · 2026Article
- Introducing Small Rings into Farnesyl Pyrophosphates Paves the Way for the Enzymatic Generation of Unnatural Sesquiterpene Scaffolds.Journal of the American Chemical Society · 2026Article
- Biodiversity-Driven Natural Products and Bioactive Metabolites.Plants (Basel, Switzerland) · 2025Review
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Systematic biotechnological production of isoprenoid analogs with bespoke carbon skeletons.Nature communications · 2025Article
- Engineering terpene synthases and their substrates for the biocatalytic production of terpene natural products and analogues.Chemical communications (Cambridge, England) · 2025Review
- Characterizing and Tailoring the Substrate Profile of a γ-Glutamyltransferase Variant.ACS synthetic biology · 2024Article
- The microbial biosynthesis of noncanonical terpenoids.Applied microbiology and biotechnology · 2024Review
- Vanadium haloperoxidases as noncanonical terpene synthases.Methods in enzymology · 2024Article
- Enhancing structural diversity of terpenoids by multisubstrate terpene synthases.Beilstein journal of organic chemistry · 2024Review
- Mining the noncanonical terpenome.Nature chemical biology · 2023Article
- Widespread biosynthesis of 16-carbon terpenoids in bacteria.Nature chemical biology · 2023Article
- Biomimetic Approach to Diverse Coral Diterpenes from a Biosynthetic Scaffold.Angewandte Chemie (International ed. in English) · 2023Article
- Exploring the Potent Anticancer Activity of Essential Oils and Their Bioactive Compounds: Mechanisms and Prospects for Future Cancer Therapy.Pharmaceuticals (Basel, Switzerland) · 2023Review
- A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast.Nature communications · 2023Review
- Chemotaxonomic Variation in Volatile Component Contents in AncientMolecules (Basel, Switzerland) · 2023Article
- Production of secondary metabolites using tissue culture-based biotechnological applications.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humankind relies on specialized metabolites for medicines, flavors, fragrances, and numerous other valuable biomaterials. However, the chemical space occupied by specialized metabolites, and, thus, their application potential, is limited because their biosynthesis is based on only a handful of building blocks. Engineering organisms to synthesize alternative building blocks will bypass this limitation and enable the sustainable production of molecules with non-canonical chemical structures, expanding the possible applications. Herein, we focus on isoprenoids and combine synthetic biology with protein engineering to construct yeast cells that synthesize 10 non-canonical isoprenoid building blocks with 16 carbon atoms. We identify suitable terpene synthases to convert these building blocks into C
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