ArticleAging clinical and experimental research2022
Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Comparison of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Radical Resection of Colon Cancer: A Single-Center Prospective Randomized Controlled Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Research Topics and Trends in MIMIC-IV: A Large ICU Database Relevant for Critical Care Nursing.Nursing in critical care · 2026Review
- A machine learning-based prediction model for sepsis-associated delirium in intensive care unit patients with sepsis-associated acute kidney injury.Renal failure · 2025Observational
- Online machine learning model for predicting delirium risk in elderly patients with chronic kidney disease: development and preliminary validation.European journal of medical research · 2025Article
- The Relationship Between the Average Infusion Rate of Propofol and the Incidence of Delirium During Invasive Mechanical Ventilation: A Retrospective Study Based on the MIMIC IV Database.CNS neuroscience & therapeutics · 2025Article
- Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study.JMIR research protocols · 2025Article
- Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database.Frontiers in neurology · 2025Article
- High level of systemic immune inflammation index elevates delirium risk among patients in intensive care unit.Scientific reports · 2024Article
- A qualitative study of geriatric specialist nurses' experiences to navigate delirium in the elderly.BMC nursing · 2024Article
- Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model-a prospective observational study.Frontiers in cardiovascular medicine · 2024Article
- Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study.Critical care research and practice · 2024Article
- The nomogram to predict the occurrence of sepsis-associated encephalopathy in elderly patients in the intensive care units: A retrospective cohort study.Frontiers in neurology · 2023Article
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6 authors.
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Abstract
backgroundAs delirium is a common problem in critcal elderly patients, the aim of the study was to investigate the interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive care unit (ICU). PATIENTS AND
methodsElderly patients (age ≥ 65) were selected from Medical Information Mart for Intensive Care (MIMIC)-IV database. Demographics data were collected on the 1st day of admission to ICU. The main outcome is in-hospital mortality. Propensity score matching analysis (PSMA) was used to remove the influence of comfounding factors between survival and nonsurvival groups. Chi-square test and logistic regression analysis was used to identify the association between delirium and in-hospital death. Stratified analysis and interaction analysis was used to evaluate the interaction factors of delirium as a risk of in-hospital mortality.
results22,361 patients were selected, and in which 2809 patients died. 5453 patients had delirium (about 24.4%). There is a significant difference in delirium between the survival and nonsurvival groups before and after PSMA (p = 0.000 and p = 0.030). Logistic regression showed delirium, sequential organ failure assessment (SOFA), and hemoglobin were all significantly related to in-hospital death (p = 0.000). SOFA score and hemoglobin concentration were proved to be remarkable interaction factors of delirium (p = 0.000, and p = 0.041). Significant correlation between delirium and hospital mortality was inhibited when SOFA was more than 12 or hemoglobin was higher than 15 g/dL. In-hospital mortality (49.1% vs. 10.5%, p = 0.000) and shock incidence (87.9% vs. 15.8%, p = 0.000) of the patients with SOFA ≥ 12 was much higher than that of the patients with SOFA ≤ 11.
conclusionSOFA and hemoglobin are interaction factors of delirium as an independent risk of in-hospital mortality in elderly patients in the intensive care unit.
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