Evidence map›Paper›PMID 36057646›Full record

ArticlePediatric research2023

Prenatal and child vitamin D levels and allergy and asthma in childhood.

Júlia Sangüesa, Jordi Sunyer, Raquel Garcia-Esteban, Alicia Abellan, Ana Esplugues, Judith Garcia-Aymerich, Mònica Guxens, Amaia Irizar, Jordi Júlvez, Leire Luque-García and 6 more

Abstract read
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In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Role of Maternal Vitamin DJournal of the American Heart Association · 2025
    Article
  5. Article
  6. Article
  7. Climate Change, Exposome Change, and Allergy: A Review.Immunology and allergy clinics of North America · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Júlia SangüesaISGlobal, Barcelona, Spain.
Jordi SunyerISGlobal, Barcelona, Spain.
Raquel Garcia-EstebanISGlobal, Barcelona, Spain.
Alicia AbellanISGlobal, Barcelona, Spain.
Ana EspluguesSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Judith Garcia-AymerichISGlobal, Barcelona, Spain.
Mònica GuxensISGlobal, Barcelona, Spain.
Amaia IrizarSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Jordi JúlvezISGlobal, Barcelona, Spain.
Leire Luque-GarcíaDepartment of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, 48940, Spain.
Ana Cristina Rodríguez-DehliSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Adonina TardónSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Maties TorrentSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Jesús VioqueSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Martine VrijheidISGlobal, Barcelona, Spain.
Maribel CasasISGlobal, Barcelona, Spain. maribel.casas@isglobal.org.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESUniversitat Pompeu Fabra · ESBarcelona Institute for Global Health · ESBiogipuzkoa Health Research Institute · ESFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHospital Universitario San Agustín · ESUniversity of Alicante · ESUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent.

objectiveTo examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort.

methods25-Hydroxyvitamin D

resultsA total of 19% of mothers and 24% of children had deficient 25(OH)D

conclusionChild 25(OH)D IMPACT: In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.

Indexed as

AsthmaDermatitis, AtopicHypersensitivityVitamin D DeficiencyChildChild, PreschoolCohort StudiesFemaleHumansPregnancyProspective StudiesRespiratory SoundsSurveys and QuestionnairesVitamin DVitaminsVitamin DVitamins

Identifiers

PMID36057646
OpenAlexW4294406023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.