ArticleNature communications2022
Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
19 citing papers in PubMed, 19 citations in OpenAlex.
- Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis.bioRxiv : the preprint server for biology · 2026Article
- Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis.Nature communications · 2026Article
- Soybean-Derived Soluble Fiber Enhances Antimicrobial Proteins in the Mouse Small Intestine via a Tuft Cell-Group 2 Innate Lymphoid Cell Axis.Journal of agricultural and food chemistry · 2026Article
- Role of Sirtuin 6 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Current issues in molecular biology · 2026Review
- SIRT6 Aggravates Psoriasiform Skin Inflammation Through Modulation of the SOCS2-STAT1/3 Pathway.Journal of inflammation research · 2026Article
- Rethinking Celiac Disease Management: Treatment Approaches Beyond the Gluten-Free Diet.Biomedicines · 2025Review
- The multifaceted role of sirtuins in inflammatory bowel diseases.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- STAT Signature Dish: Serving Immunity with a Side of Dietary Control.Biomolecules · 2025Review
- Review
- Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity.Current stem cell research & therapy · 2025Article
- Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024Review
- Histone acylations as a mechanism for regulation of intestinal epithelial cells.Digestive medicine research · 2024Article
- Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health.Annual review of physiology · 2024Review
- Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production.Frontiers in immunology · 2024Article
- Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling.Nature communications · 2023Article
- Hookworms dynamically respond to loss of Type 2 immune pressure.PLoS pathogens · 2023Article
- TRAF3/STAT6 axis regulates macrophage polarization and tumor progression.Cell death and differentiation · 2023Article
- Interactions between Intestinal Homeostasis and NADNutrients · 2023Review
- Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused byInternational journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 2 countries.
Xiwen XiongSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China. xwxiong@xxmu.edu.cn.ORCID 0000-0001-5802-4994
Chenyan YangSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Wei-Qi HeJiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.ORCID 0000-0003-3137-8420
Jiahui YuSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Yue XinSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Xinge ZhangSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Rong HuangSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Honghui MaSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Shaofang XuJiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, China.
Zun LiSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Jie MaSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Lin XuSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Qunyi WangThe Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Kaiqun RenHunan Normal University School of Medicine, Changsha, Hunan, 410013, China.
Xiaoli S WuCold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.
Christopher R VakocCold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.ORCID 0000-0002-1158-7180
Jiateng ZhongSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Genshen ZhongSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.ORCID 0000-0003-2086-3834
Xiaofei ZhuSchool of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Yu SongSchool of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.ORCID 0000-0002-3858-1272
Qingzhi WangSchool of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China. wqzmgl@126.com.
Xinxiang Medical University · CNCold Spring Harbor Laboratory · USSoochow University · CNHunan Normal University · CNUniversity of Minnesota Medical Center · US
Funding
Intestinal O-GlcNAc signaling and mucosal host defenseR01AI162791 · NIAID · UNIVERSITY OF MINNESOTA · PI Hai-Bin Ruan · 2022 to 2026
$2.4MExploiting POU2F3 addiction in the tuft cell variant of small cell lung cancerU01CA242919 · NCI · COLD SPRING HARBOR LABORATORY · PI VAKOC, CHRISTOPHER · 2019 to 2023
$2.2MNCI NIH HHS U01 CA242919NIAID NIH HHS R01 AI162791
Abstract
Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs to the NAD
Indexed as
Intestinal MucosaAnimalsEpithelial CellsGoblet CellsHelminthiasisImmunity, MucosalIntestinesMiceMice, Inbred C57BLMice, TransgenicSirtuinsSTAT6 Transcription FactorSirt6 protein, mouseSirtuinsStat6 protein, mouseSTAT6 Transcription Factor
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.