ArticleAddiction science & clinical practice2022
Coping motives mediate the relationship between PTSD and MDMA use in adolescents with substance use disorders.
Article in Addiction science & clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Lifetime MDMA use and associations with meaning in life in the context of childhood trauma.Scientific reports · 2026Article
- Study of the effect of post-traumatic stress disorder and comorbid disorders on the daily lives of schoolchildren aged 11 to 16 in public schools in Morocco.Health psychology report · 2026Article
- Effect of comorbid psychologic and somatic symptom trajectories on early onset substance use among U.S. youth in the ABCD study.Addictive behaviors · 2025Article
- MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations.European child & adolescent psychiatry · 2024Review
- PTSD, dysregulation profile and substance use: exploring differences in a sample of adolescents in an outpatient clinic.Frontiers in child and adolescent psychiatry · 2024Article
- Attenuated psychotic symptoms, substance use and self-reported PTSD in adolescence.European journal of psychotraumatology · 2023Article
- Evaluation of the multimodal DELTA therapy for adolescents with substance use disorders: an exploratory pilot trial.Frontiers in psychiatry · 2023Article
- Prevalence and Correlates of Lifetime Ecstasy/MDMA Use Among Asian American and Pacific Islander Adult Populations in the United States, 2015-2020.Journal of psychoactive drugsArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-traumatic stress disorder (PTSD) and substance use disorders (SUDs) often co-occur in adolescent patients. Previous research has shown that these patients differ from SUD patients without PTSD in terms of their substance use patterns. In this study, we aimed to test whether substance use in this population is related to an attempt to self-medicate PTSD-related symptoms.
methodsGerman adolescent patients (aged 13-18 years) at an outpatient clinic for SUD treatment, n = 111 (43% female), completed a self-designed questionnaire on use motives, a measure of PTSD-related experiences, and underwent a standardized psychiatric interview including structured substance use questions. Participants were subsequently classified as 'no traumatic experiences ('noTEs' but SUD), 'traumatic experiences but no current PTSD diagnosis' ('TEs' with SUD), and 'PTSD' with SUD. After establishing a self-designed motive measurement through exploratory and confirmatory factor analyses, we calculated non-parametric group differences and a mediation analysis in a linear regression framework.
resultsThe past-year frequency of MDMA use was highest in the PTSD group and lowest in the noTE group (H (2) = 7.2, p = .027, η
conclusionsIn adolescent SUD patients, we found an association of current PTSD and lifetime traumatic experiences with higher MDMA use that could be partially explained by substance use being motivated by an attempt to cope with mental health symptoms. This indicates a coping process involved specifically in MDMA use compared to the use of other psychoactive substances, possibly due to unique psychoactive effects of MDMA.
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