Evidence map›Paper›PMID 36057554›Full record

ArticleBMC nephrology2022

Development and Validation of a Kidney-Transplant Specific Measure of Treatment Burden.

Elizabeth C Lorenz, Tanya M Petterson, Isabella Zaniletti, Kandace A Lackore, Bradley K Johnson, Martin L Mai, Sumi S Nair, Andrew J Bentall, Kathleen J Yost, David T Eton

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth C LorenzWilliam J Von Liebig Center for Transplantation and Clinical Regeneration, Rochester, MN, USA. lorenz.elizabeth@mayo.edu.ORCID 0000-0003-1012-9409
Tanya M PettersonDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4075-7334
Isabella ZanilettiQuantitative Health Sciences, Mayo Clinic, Scottsdale, AZ, USA.ORCID 0000-0003-1234-3468
Kandace A LackoreDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9215-5138
Bradley K JohnsonDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9005-3434
Martin L MaiWilliam J Von Liebig Center for Transplantation and Clinical Regeneration, Rochester, MN, USA.
Sumi S NairWilliam J Von Liebig Center for Transplantation and Clinical Regeneration, Rochester, MN, USA.
Andrew J BentallWilliam J Von Liebig Center for Transplantation and Clinical Regeneration, Rochester, MN, USA.ORCID 0000-0002-8495-9782
Kathleen J YostDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9641-5627
David T EtonDivision of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-8715-1511
Mayo Clinic in Florida · USMayo Clinic · USMayo Clinic in Arizona · USWinnMed · US

Funding

Improving frailty and long-term outcomes after kidney transplantationK23DK123313 · NIDDK · MAYO CLINIC ROCHESTER · PI LORENZ, ELIZABETH C. · 2019 to 2023
$795k
NIDDK NIH HHS K23 DK123313
6 · The paper itself

Abstract

backgroundTreatment burden refers to the work involved in managing one's health and its impact on well-being and has been associated with nonadherence in patients with chronic illnesses. No kidney transplant (KT)-specific measure of treatment burden exists. The aim of this study was to develop a KT-specific supplement to the Patient Experience with Treatment and Self-Management (PETS), a general measure of treatment burden.

methodsAfter drafting and pretesting KT-specific survey items, we conducted a cross-sectional survey study involving KT recipients from Mayo Clinic in Minnesota, Arizona, and Florida. Exploratory factor analysis (EFA) was used to identify domains for scaling the KT-specific supplement. Construct and known-groups validity were determined.

resultsSurvey respondents (n = 167) had a mean age of 61 years (range 22-86) and received a KT on average 4.0 years ago. Three KT-specific scales were identified (transplant function, self-management, adverse effects). Higher scores on the KT-specific scales were correlated with higher PETS treatment burden, worse physical and mental health, and lower self-efficacy (p < 0.0001). Patients taking more medications reported higher transplant self-management burden.

conclusionsWe developed a KT-specific supplement to the PETS general measure of treatment burden. Scores may help providers identify recipients at risk for nonadherence.

Indexed as

Kidney TransplantationSelf-ManagementAdultAgedAged, 80 and overCross-Sectional StudiesHumansMiddle AgedSurveys and QuestionnairesTransplant RecipientsYoung AdultAdherenceChronic Kidney DiseaseKidney TransplantQuality of LifeTreatment Burden

Identifiers

PMID36057554
PMCPMC9440455
OpenAlexW4294408990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.