ReviewTrends in neurosciences2022
A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.
Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Comprehensive investigation of predictive processing: A cross- and within-cognitive domains fMRI meta-analytic approach.Human brain mapping · 2024Pooled it
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Bidirectional brain-heart interactions in health and disease.Nature reviews. Neurology · 2026Review
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health.Neuroscience · 2025Review
- Cardiovascular risk factors and the allostatic interoceptive network in dementia.Cardiovascular research · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- Social exposome and brain health outcomes of dementia across Latin America.Nature communications · 2025Article
- The exposome of healthy and accelerated aging across 40 countries.Nature medicine · 2025Article
- Resilience and brain health in global populations.Nature medicine · 2025Review
- Interplay Between Cortical and Neurocardiac Interoceptive Processes and its Association with Self-Reported Interoceptive Sensibility.Brain topography · 2025Article
- Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults.Journal of the American Heart Association · 2025Article
- Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings.EClinicalMedicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent allostatic-interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this framework could explain divergent deficits in bvFTD (cognitive impairments, behavioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopathological mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.