Evidence map›Paper›PMID 36057027›Full record

SynthesisUpdates in surgery2022

Meta-analysis of survival after extrapleural pneumonectomy (EPP) versus pleurectomy/decortication (P/D) for malignant pleural mesothelioma in the context of macroscopic complete resection (MCR).

Dimitrios E Magouliotis, Prokopis-Andreas Zotos, Arian Arjomandi Rad, Despoina Koukousaki, Vasiliki Vasilaki, Ioustini Portesi, Kyriakos Spiliopoulos, Thanos Athanasiou

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Updates in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dimitrios E MagouliotisDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece. dimitrios.magouliotis.18@ucl.ac.uk.ORCID http://orcid.org/0000-0001-5417-6392
Prokopis-Andreas ZotosDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Arian Arjomandi RadDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Despoina KoukousakiDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Vasiliki VasilakiDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Ioustini PortesiDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Kyriakos SpiliopoulosDepartment of Cardiothoracic Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Thanos AthanasiouDepartment of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, W2 1NY, UK.
University of Thessaly · GRImperial College London · GBSt Mary's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe reviewed the available literature on patients with MPM undergoing either extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D).

methodsOriginal research studies that evaluated long-term outcomes of P/D versus EPP were identified, from January 1980 to February 2022. The 30-days and 90-day mortality, along with the 1-, 2-, 3-, 5-year survival, the median overall survival, the macroscopic complete resection (MCR) rate, and the complications were calculated according to both a fixed and a random effect model. The Q and I

resultsEighteen studies were included, incorporating a total of 4,852 patients treated with EPP and P/D. The 30-day mortality was significantly higher in the EPP group (OR: 2.79 [95% CI 1.30, 6.01]; p = 0.009). The median overall survival was higher in the P/D group (WMD:-4.55 [-6.05, -3.04]; p < 0.001). No differences were found regarding the 90-day mortality, MCR rate, and the 1-, 2-,3-, 5-year survival between the EPP and P/D groups. These findings were validated by the sensitivity analysis. The incidence of atrial fibrillation, hemorrhage, pulmonary embolism, air leak, and reoperation was significantly increased in the EPP group (p < 0.05).

conclusionsThe present meta-analysis indicates that P/D is associated with enhanced outcomes regarding 30-day mortality, median overall survival, and complications. The P/D approach should be preferred when technically feasible. However, the procedure of choice should be decided based on the goal of MCR in the safest approach for the patient.

Indexed as

Mesothelioma, MalignantPneumonectomyHumansOutcome Assessment, Health CareReoperationDecorticationExtrapleural pneumonectomyMacroscopic complete resectionMalignant pleural mesotheliomaPleurectomy

Identifiers

PMID36057027
OpenAlexW4294405700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.