ArticleActa obstetricia et gynecologica Scandinavica2022
National register data are of value in studies on miscarriage-Validation of the healthcare register data in Finland.
Article in Acta obstetricia et gynecologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Induced abortion, miscarriage, and the risk of breast cancer-A registry-based study from Finland.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Patterns of Prior Induced Abortions and the Likelihood of Subsequent Natural Pregnancy Loss: Exploratory Application of Pregnancy Outcome Sequencing.JMIR formative research · 2025Article
- First birth and total fertility rate in women with surgically verified endometriosis - A nationwide register study of 18 320 women across reproductive life course.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Miscarriage treatment-related adverse events: A nationwide registry study from Finland.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Excess of severe autoimmune diseases in women with premature ovarian insufficiency: a population-based study.Human reproduction (Oxford, England) · 2024Article
- Epidemiology of spontaneous pregnancy loss in Kazakhstan: A national population-based cohort analysis during 2014-2019 using the national electronic healthcare system.Acta obstetricia et gynecologica Scandinavica · 2023Article
- First live birth before surgical verification of endometriosis-a nationwide register study of 18 324 women.Human reproduction (Oxford, England) · 2023Article
- National register data are of value in studies on miscarriage-Validation of the healthcare register data in Finland.Acta obstetricia et gynecologica Scandinavica · 2022Article
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7 authors.
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Abstract
introductionDespite the high prevalence of miscarriages, they are not systematically registered and few epidemiological studies have been done. As Finnish health registries are comprehensive and widely used in research, we validated the Finnish register data concerning diagnostics and treatment of miscarriage, and treatment-related adverse events. MATERIAL AND
methodsWe conducted a validation study regarding miscarriage-related codes of diagnoses and surgical procedures in a Finnish National Hospital Discharge Registry (NHDR) by comparing the information from the NHDR with that of the hospital records. We selected a random sample of 4 months during 1998-2016 from three hospitals, comprising 687 women aged 15-49 experiencing a first miscarriage during follow-up. Women with diagnoses unrelated to miscarriage, or proven to be other than miscarriage, were excluded. The final sample consisted of 643 women with confirmed miscarriage, which was used for analyses regarding the diagnosis, treatment and adverse events of miscarriage treatment.
resultsThe majority of miscarriages registered in the NHDR were confirmed by the hospital records (positive predictive value [PPV] = 93.6% [95% confidence interval [CI] 91.8%-95.4%]). Different types of miscarriage were also reliably identified; spontaneous abortion with PPV = 85.6% (95% CI 80.9%-89.2%), missed abortion with PPV = 92.7% (95% CI 88.8%-95.3%) and blighted ovum with PPV = 91.1% (95% CI 84.3%-95.1%). The PPV of surgical treatment (62.2% [95% CI 55.7%-68.3%]) was lower than the PPV of non-surgical treatment (93.3% [95% CI 90.5%-95.3%]). The diagnoses regarding adverse events of miscarriage treatment could be reliably identified. The PPV for clinical infections was 76.0% (95% CI 56.6%-88.5%) and for retained products of conception or/and vaginal bleeding 96.8% (95% CI 83.8%-99.4%).
conclusionsThe coverage of the NHDR was good concerning identification of miscarriages, different types of miscarriages and non-surgical treatment. Nevertheless, there is a need for clearly defined procedural codes concerning to medical treatment of miscarriage. The register-based data are reliable and practicable for both clinical evaluation and research concerning miscarriage.
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