Evidence map›Paper›PMID 36056910›Full record

ArticleJournal of cutaneous pathology2023

Line-field confocal optical coherence tomography of lentigo maligna with horizontal and vertical histopathologic correlations.

Anna Elisa Verzì, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Micali, Francesco Lacarrubba

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of cutaneous pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Use of non-invasive optical imaging techniques in dermatology.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Review
  4. Comparison of facial skin ageing in healthy Asian and Caucasian females quantified by in vivo line-field confocal optical coherence tomography 3D imaging.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  5. Review
  6. Lentigo Maligna Treatment-An Update.Journal of clinical medicine · 2024
    Review
  7. Article
  8. Line-field confocal optical coherence tomography of eyelid margin growths: A case series.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna Elisa VerzìDermatology Clinic, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-3274-6099
Giuseppe BroggiDepartment "G.F. Ingrassia," Section of Anatomic Pathology, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0003-2576-6523
Rosario CaltabianoDepartment "G.F. Ingrassia," Section of Anatomic Pathology, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0001-8591-8010
Giuseppe MicaliDermatology Clinic, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-5157-3939
Francesco LacarrubbaDermatology Clinic, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-0860-2060
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lentigo maligna (LM) is a subtype of in situ melanoma that classically presents in elderly patients as a slowly growing lesion on sun-exposed areas that may evolve to invasive melanoma. Line-field confocal optical coherence tomography (LC-OCT) is a new non-invasive technique for a real-time, vertical, and horizontal skin imaging with high resolution close to conventional histopathology. We present the LC-OCT features of an LM of the nose in a 49-year-old white man along with their horizontal and vertical histopathological correlations. LC-OCT was able to detect in vivo, in both horizontal and vertical imaging, the main microscopic features typical of LM by showing, in the epidermis and around the hair follicles, the presence of large, bright roundish, or dendritic atypical cells, with evident nuclei, corresponding to atypical melanocytes with a tendency toward folliculotropism. A strong correspondence between LC-OCT images and vertical and horizontal histopathological sections was observed. Our study, although limited to a single case, is indicative of the great potential of LC-OCT to improve the non-invasive diagnosis of LM.

Indexed as

Hutchinson's Melanotic FreckleMelanomaSkin NeoplasmsAgedHumansMaleMicroscopy, ConfocalMiddle AgedSkinTomography, Optical Coherencedermoscopydiagnosishistopathologylentigo malignaline-field confocal optical coherence tomography

Identifiers

PMID36056910
PMCPMC10087826
OpenAlexW4294406033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.