ReviewJournal of the American Heart Association2022
Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider.
Review in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Safety and Efficacy of Zero Fluoroscopy Patent Ductus Arteriosus Closure in Comparison to the Standardized Fluoroscopy-Guided Procedure: A Systematic Review and Meta-Analysis.Current cardiology reviews · 2025Pooled it
- Brazilian Guideline for Exercise Testing in Children and Adolescents - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Higher (40%) versus lower (30%) FiOEuropean journal of pediatrics · 2025Trial
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Universal practice based management of patent ductus arteriosus in premature neonates in 2025: BRONX PDA protocol and BRONX clinical scoring system (BCSS).Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Expert consensus on bedside transcatheter closure of patent ductus arteriosus in extremely low birth weight infants.Pediatric research · 2026Article
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- The clinical utility of paracetamol serum concentration monitoring for patent ductus arteriosus treatment in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Physiological-Based Cord Clamping and Early Oxygenation in Newborns With Transposition of the Great Arteries: A Quality Improvement Study Protocol.CJC pediatric and congenital heart disease · 2026Article
- Ibuprofen for hemodynamically significant patent ductus arteriosus in extremely preterm infants: a target trial emulation.Translational pediatrics · 2026Article
- Beyond diameter: redefining echocardiography criteria in trials of early PDA therapy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Prolonged patent ductus arteriosus exposure and risk for late acute kidney injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Stealing nephrons-a review on how patent ductus arteriosus physiology impacts neonatal kidney health.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- The Ductus Dilemma: To Close or Not to Close in the Fight Against Endocarditis/Endarteritis.Children (Basel, Switzerland) · 2026Review
- Evaluating the Effectiveness of Ibuprofen Versus Acetaminophen in Closing Patent Ductus Arteriosus in Preterm Neonates.Children (Basel, Switzerland) · 2026Article
- Effectiveness of Ibuprofen Arginine, Ibuprofen Lysine, and Indomethacin for Patent Ductus Arteriosus Closure in Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Evaluation ofJournal of cardiovascular development and disease · 2026Article
- Transcatheter closure of PDA: how the pathway changed from classical fluoroscopy approach.Frontiers in cardiovascular medicine · 2026Article
- Case Report: Percutaneous closure of patent ductus arteriosus with the KONAR-MF™ device: initial experience and results at 6 months in a tertiary center.Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The burden of patent ductus arteriosus (PDA) continues to be significant. In view of marked differences in preterm infants versus more mature, term counterparts (viewed on a continuum with adolescent and adult patients), mechanisms regulating ductal patency, genetic contributions, clinical consequences, and diagnostic and treatment thresholds are discussed separately, when appropriate. Among both preterm infants and older children and adults, a range of hemodynamic profiles highlighting the markedly variable consequences of the PDA are provided. In most contemporary settings, transcatheter closure is preferable over surgical ligation, but data on longer-term outcomes, particularly among preterm infants, are lacking. The present review provides recommendations to identify gaps in PDA diagnosis, management, and treatment on which subsequent research can be developed. Ultimately, the combination of refined diagnostic thresholds and expanded treatment options provides the best opportunities to address the burden of PDA. Although fundamental gaps remain unanswered, the present review provides pediatric and adult cardiac care providers with a contemporary framework in PDA care to support the practice of evidence-based medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.