Evidence map›Paper›PMID 36056624›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

Fracture Risk in Pediatric Patients With MEN2B.

Iris Li, Iris R Hartley, Joanna Klubo-Gwiedzdzinska, James C Reynolds, Barbara J Thomas, Julie Hogan, Mahider M Enyew, Eva Dombi, Alexander Ling, Srivandana Akshintala and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Iris LiPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Iris R HartleySkeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
Joanna Klubo-GwiedzdzinskaMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID 0000-0001-8633-4420
James C ReynoldsRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Barbara J ThomasPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Julie HoganPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Mahider M EnyewPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Eva DombiPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID 0000-0002-5323-6995
Alexander LingRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
Srivandana AkshintalaPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
David J VenzonBiostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Jaydira Del RiveroDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID 0000-0001-9710-4030
Michael CollinsSkeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
John W GlodPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID 0000-0002-3071-7876
National Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

MyPART: My Pediatric and Adult Rare Tumor Network - CuresZIABC011852 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WIDEMANN, BRIGITTE · 2020 to 2025
$39.2M
Division of Intramural Research National Cancer InstituteIntramural NIH HHS ZIA BC011852NCI NIH HHS HHSN261200800001ENIH HHS
6 · The paper itself

Abstract

contextThe skeletal phenotype of patients with MEN2B has been described but fracture risk in these patients has not yet been evaluated.

objectiveThis work aims to better delineate fracture risk in patients with multiple endocrine neoplasia type 2B (MEN2B).

methodsThis case series with chart review was conducted at the National Institutes of Health, Pediatric Oncology Branch. A total of 48 patients with MEN2B were identified, with an age range of 5 to 36 years, median of 19; 24 of 48 (50%) patients were female. Medical records, demographic information, available imaging, and laboratory results were reviewed. History up to age 19 was included in the statistical analyses.

resultsOf the 48 patients with MEN2B, 20 patients experienced at least one fracture. The majority (n = 18) experienced their first fracture at or before age 19. The observed frequency of fracture occurrence throughout childhood (0-19 years) was 38%, with very little difference between males and females. This frequency is higher than the 9.47 to 36.1 fractures per 1000 persons per year that has been reported in healthy pediatric cohorts in the United States. Less common sites of fracture including vertebral compression fracture and pelvic fractures were observed in patients with MEN2B.

conclusionIn this group of patients with MEN2B, there was an increased overall risk of fracture compared to general pediatric cohorts in the United States. Less common sites of fracture were also observed. This suggests a possible effect of an activating RET mutation on bone physiology and warrants further investigation.

Indexed as

Fractures, CompressionMultiple Endocrine Neoplasia Type 2bSpinal FracturesFemaleHumansMalePhenotypeProto-Oncogene Proteins c-retProto-Oncogene Proteins c-retfractureMEN2Bpediatric

Identifiers

PMID36056624
PMCPMC10233495
OpenAlexW4294363599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.