Evidence map›Paper›PMID 36056604›Full record

ArticleAging cell2022

IgD

Olivia Kugler-Umana, Wenliang Zhang, Yi Kuang, Jialing Liang, Catherine H Castonguay, Susan L Tonkonogy, Ann Marshak-Rothstein, Priyadharshini Devarajan, Susan L Swain

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  9. Review
  10. IgDAging cell · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Olivia Kugler-UmanaDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-4378-8291
Wenliang ZhangDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Yi KuangDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Jialing LiangDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Catherine H CastonguayDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Susan L TonkonogyCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Ann Marshak-RothsteinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Priyadharshini DevarajanDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Susan L SwainDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-3643-8018
University of Massachusetts Chan Medical School · USNorth Carolina State University · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
MOLECULAR BIOLOGY COREP01AG021600 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2003 to 2016
$24.4M
T cell memory to TB in the lungP01AI046530 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI COOPER, ANDREA M · 1999 to 2013
$22.2M
THE CTL REPERTOIRE OF AGED MICEP01AG001743 · NIA · SCRIPPS RESEARCH INSTITUTE · PI KLINMAN, NORMAN R · 1985 to 2004
$8.7M
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5M
Impact of aging on naive CD4 T cell functionR37AG025805 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2005 to 2014
$3.9M
Defining a memory checkpoint for CD4 T cellsR01AI118820 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2015 to 2019
$2.1M
THE ROLE OF HELPER T CELLS IN THE B CELL RESPONSER37AI022125 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SWAIN, SUSAN L · 1995 to 2004
$1.9M
How Distinct Age-Associated B Cell Subsets Can Protect the Aged from InfluenzaR01AI179760 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Susan L Swain · 2024 to 2026
$1.8M
Enhancing the success of underrepresented students in the biomedical sciencesR25GM113686 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LAPANE, KATE L, LEWIS, BRIAN C · 2015 to 2019
$1.7M
Training in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6M
Age-Associated B Cells Specialized for Immunity to Pathogens?R21AG068313 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2021 to 2022
$461k
NIAID NIH HHS P01 AI046530NIAID NIH HHS R01 AI118820NIAID NIH HHS R01 AI179760NIAID NIH HHS R37 AI022125NIAID NIH HHS T32 AI007349NIAID NIH HHS T32 AI132152NIA NIH HHS P01 AG001743NIA NIH HHS P01 AG021600NIA NIH HHS R21 AG058758NIA NIH HHS R21 AG068313NIA NIH HHS R37 AG025805NIDDK NIH HHS P30 DK034987NIGMS NIH HHS R25 GM113686
6 · The paper itself

Abstract

Age-associated B cells (ABC) accumulate with age and are associated with autoimmunity and chronic infection. However, their contributions to acute infection in the aged and their developmental pathways are unclear. We find that the response against influenza A virus infection in aged mice is dominated by a Fas

Indexed as

Influenza, HumanInfluenza VaccinesAnimalsAntibodies, ViralB-LymphocytesHumansImmunoglobulin DImmunoglobulin GImmunoglobulin MMiceT-LymphocytesToll-Like Receptor 7Toll-Like Receptor 9Vaccines, InactivatedAntibodies, ViralImmunoglobulin DImmunoglobulin GImmunoglobulin MInfluenza VaccinesToll-Like Receptor 7Toll-Like Receptor 9Vaccines, Inactivatedadaptive immunityage-associated B cellsaginginfluenzaTLR signals

Identifiers

PMID36056604
PMCPMC9577953
OpenAlexW4294368798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.