ArticleAnnals of clinical and translational neurology2022
Vestibular syncope: clinical characteristics and mechanism.
Article in Annals of clinical and translational neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Mechanistic Pathways Linking Type 2 Diabetes Mellitus, Hypertension, and Osteoarthritis to Falls in Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- A Rare Case of Anterior Semicircular Canal BPPV Resistant to Treatment: A Case Report and Literature Review.Audiology research · 2025Article
- Recurrent carotid sinus syncope in a middle-aged woman without any underlying condition: a case report.Annals of medicine and surgery (2012) · 2025Article
- Update on Clinical Physiology and Pathomechanisms for Vestibulo-Autonomic Interplay.Cerebellum (London, England) · 2025Review
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Vestibular Syncope and Acute Peripheral Vestibular Deficit: A Case Report.Clinical case reports · 2024Article
- Blood Pressure Variability and Ocular Vestibular-Evoked Myogenic Potentials Are Independently Associated With Orthostatic Hypotension.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Disrupted Rotational Perception During Simultaneous Stimulation of Rotation and Inertia.Cerebellum (London, England) · 2024Article
- Vermian multinodular and vacuolating lesion of unknown significance discovered following syncope: a case report.Annals of medicine and surgery (2012) · 2024Article
- Posterior Semicircular Canal Plugging Relieves Tumarkin's Crisis in Ménière's Disease Patients.Audiology research · 2024Article
- Presence of Spontaneous Nystagmus, Benign Paroxysmal Positional Vertigo, and Tumarkin Fall in Patients With Primary Headache and Their Responses to Caloric and Video Head Impulse Tests.Journal of clinical medicine research · 2024Article
- Neurological update: neuro-otology 2023.Journal of neurology · 2023Article
- Periodic vertigo and downbeat nystagmus while supine: Dysfunction of Purkinje cells coding gravity.Annals of clinical and translational neurology · 2023Article
- Augmented ocular vestibular-evoked myogenic potentials in postural orthostatic tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Effect of a False Inertial Cue in the Velocity-Storage Circuit on Head Posture and Inertia Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The role of otolith reflexes in orthostatic intolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesVestibular syncope is a condition in which vertigo-induced hemodynamic changes cause syncope. This study investigated the clinical and laboratory findings of vestibular syncope and tried to refine our knowledge of the mechanism underlying this newly recognized entity.
methodsThis study retrospectively analyzed 53 patients (33 women, median age = 63 years [interquartile range = 54-71 years]) with vestibular syncope from January 2017 to December 2021. To explain the mechanism of vestibular syncope, we incorporated a velocity-storage model into the dual reflex pathways comprising the vestibulo-sympathetic reflex and baroreflex and predicted the cardiovascular responses.
resultsTwenty (37.7%) patients had multiple episodes of vestibular syncope, and seven (13.2%) had potentially life-threatening injuries. Meniere's disease (20.8%) and benign paroxysmal positional vertigo (9.4%) were the most common underlying vestibular disorders. Abnormal vestibular function tests included impaired cervical vestibular-evoked myogenic potentials (57.5%) and positive head impulse tests (31.0%). Orthostatic hypotension was found in 19.5% of patients. Dyslipidemia (30.2%) and hypertension (28.3%) were common medical comorbidities. The dual reflex pathways incorporating the function of the velocity-storage circuit in the brainstem and cerebellum suggest that vestibular syncope is a neurally mediated reflex syncope associated with a sudden hemodynamic change during vertigo. This change can be arterial hypertension triggered by a false downward inertial cue, as suggested previously, or hypotension driven by a false upward inertial cue.
conclusionsVestibular syncope is associated with various vestibular disorders and requires careful evaluation and intervention to prevent recurrent falls and significant injuries.
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