Evidence map›Paper›PMID 36056167›Full record

ArticleCell regeneration (London, England)2022

Rise of the human-mouse chimeric brain models.

Peng Jiang, Mahabub Maraj Alam

Open access · diamondAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Astrocytes as Therapeutic Targets in Neurodegenerative Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Rag2Stem cell reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peng JiangDepartment of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ, 08854, USA. peng.jiang@rutgers.edu.
Mahabub Maraj AlamDepartment of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ, 08854, USA.
Rutgers, The State University of New Jersey · US

Funding

A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down SyndromeR01AG073779 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI Peng Jiang · 2021 to 2026
$3.1M
Understanding Down Syndrome Brain Development Using Human iPSC-Based Mouse ChimerasR01NS122108 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Peng Jiang · 2021 to 2026
$2.1M
Novel Functions of OLIG2 in Regulating Human Interneuron Production in Health and DiseaseR01NS102382 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI JIANG, PENG · 2018 to 2022
$1.6M
NIA NIH HHS R01 AG073779NINDS NIH HHS R01 NS102382NINDS NIH HHS R01 NS122108
6 · The paper itself

Abstract

Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.

Indexed as

AstrogliaChimeraHuman pluripotent stem cellsMacrogliaMicrogliaNeurological DisordersNeuronsOligodendroglia

Identifiers

PMID36056167
PMCPMC9440171
OpenAlexW4294543123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.