Evidence map›Paper›PMID 36056136›Full record

ArticleScientific reports2022

Changes in immunological parameters by ageing in rural healthy Indian adults and their associations with sex and lifestyle.

Dhiraj Agarwal, Sourav Paul, Pallavi Lele, Vikrant Piprode, Anand Kawade, Neerja Hajela, Ashish Bavdekar, Varsha Parulekar, Manisha Ginde, Gandhali Paranjape and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Dhiraj Agarwal *KEM Hospital Research Centre, Vadu Rural Health Program, Pune, Maharashtra, 412216, India.
Sourav Paul *National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, Maharashtra, 411007, India.
Pallavi LeleKEM Hospital Research Centre, Vadu Rural Health Program, Pune, Maharashtra, 412216, India.
Vikrant PiprodeNational Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, Maharashtra, 411007, India.
Anand KawadeKEM Hospital Research Centre, Vadu Rural Health Program, Pune, Maharashtra, 412216, India.
Neerja HajelaYakult Danone India Pvt. Ltd., 212, Ground Floor, Okhla Industrial Estate Phase-III, New Delhi, Delhi, 110020, India.
Ashish BavdekarPaediatrics Department, KEM Hospital Research Centre, Pune, Maharashtra, 411011, India.
Varsha ParulekarDiagnoSearch Life Sciences Pvt. Ltd., 702, Dosti Pinnacle Plot No. E-7, Road No. 22 Wagle Industrial Estate, Thane, Maharashtra, 400604, India.
Manisha GindeDiagnoSearch Life Sciences Pvt. Ltd., 702, Dosti Pinnacle Plot No. E-7, Road No. 22 Wagle Industrial Estate, Thane, Maharashtra, 400604, India.
Gandhali ParanjapeDiagnoSearch Life Sciences Pvt. Ltd., 702, Dosti Pinnacle Plot No. E-7, Road No. 22 Wagle Industrial Estate, Thane, Maharashtra, 400604, India.
Kazunori MatsudaYakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.
Tetsuji HoriYakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.
Sanjay JuvekarKEM Hospital Research Centre, Vadu Rural Health Program, Pune, Maharashtra, 412216, India.
Girdhari LalNational Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune, Maharashtra, 411007, India. glal@nccs.res.in.
Dr. D. Y. Patil Medical College, Hospital and Research Centre · INNational Centre for Cell Science · INYakult Central Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several factors including sex and lifestyle have been reported to contribute to the age-related alteration of immune functions. The study was undertaken to determine age-related differences in the proportion of peripheral blood mononuclear lymphocytes in the Indian population using blood samples from 67 healthy adults (33 females and 34 males) aged between 20 and 80 years old. In the linear regression analysis to estimate the relationship with age categories, there was a significant increase in the frequency of natural killer cells with ageing, while their cytolytic activity significantly declined. The frequency of CD4

Indexed as

CD8-Positive T-LymphocytesLeukocytes, MononuclearAdultAgedAged, 80 and overAgingFemaleFlow CytometryHumansLife StyleMaleMiddle AgedYoung Adult

Identifiers

PMID36056136
PMCPMC9438881
OpenAlexW4294266783

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.