Evidence map›Paper›PMID 36056060›Full record

ArticleScientific reports2022

Amoebicidal activity of cationic carbosilane dendrons derived with 4-phenylbutyric acid against Acanthamoeba griffini and Acanthamoeba polyphaga trophozoites and cysts.

P López-Barona, C Verdú-Expósito, T Martín-Pérez, N Gómez-Casanova, T Lozano-Cruz, P Ortega, R Gómez, J Pérez-Serrano, I Heredero-Bermejo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

P López-BaronaDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain.
C Verdú-ExpósitoDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain.
T Martín-PérezDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain.
N Gómez-CasanovaDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain.
T Lozano-CruzDepartment of Organic and Inorganic Chemistry, Andrés M. del Río Chemistry Research Institute (IQAR), Ramón y Cajal Health Research Institute (IRYCIS), Bioengineering, Biomaterials and Nanomedicine Networking Research Center (CIBER-BBN), University of Alcalá, 28871, Madrid, Spain.
P OrtegaDepartment of Organic and Inorganic Chemistry, Andrés M. del Río Chemistry Research Institute (IQAR), Ramón y Cajal Health Research Institute (IRYCIS), Bioengineering, Biomaterials and Nanomedicine Networking Research Center (CIBER-BBN), University of Alcalá, 28871, Madrid, Spain.
R GómezDepartment of Organic and Inorganic Chemistry, Andrés M. del Río Chemistry Research Institute (IQAR), Ramón y Cajal Health Research Institute (IRYCIS), Bioengineering, Biomaterials and Nanomedicine Networking Research Center (CIBER-BBN), University of Alcalá, 28871, Madrid, Spain.
J Pérez-SerranoDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain.
I Heredero-BermejoDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871, Alcalá de Henares, Spain. irene.heredero@uah.es.
Universidad de Alcalá · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amoebae from the genus Acanthamoeba are important pathogens responsible for severe illnesses in humans such as Acanthamoeba keratitis and granulomatous amoebic encephalitis. In the last few decades, AK diagnoses have steadily increased. Most patients suffering from AK were contact lens users and the infection was related to poor hygiene. However, therapy is not yet well established, and treatments may last for several months due to resistance. Moreover, these treatments have been described to generate cytotoxicity. Therefore, there is an urgent need to develop new therapeutic strategies against AK. In this study, the amoebicidal activity of different generation cationic carbosilane dendrons derived with 4-phenylbutyric acid was demonstrated against Acanthamoeba polyphaga and Acanthamoeba griffini trophozoites and cysts. In addition, the combination of chlorhexidine digluconate and the most effective dendron (ArCO

Indexed as

AcanthamoebaAcanthamoeba castellaniiAmebicidesCystsDendrimersAnimalsCationsHumansPhenylbutyratesSilanesTrophozoites4-phenylbutyric acidAmebicidescarbosilaneCationsDendrimersPhenylbutyratesSilanes

Identifiers

PMID36056060
PMCPMC9440212
OpenAlexW4294243259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.