ArticleNature communications2022
Spatiotemporal control of signal-driven enzymatic reaction in artificial cell-like polymersomes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Elucidating the Reciprocal Interplay between Supramolecular Polymer Cytoskeletons and Fuel-Dependent Synthetic Cells.Journal of the American Chemical Society · 2026Article
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Adaptive Coacervate Microreactors with Broad pH/Thermal Tolerance for Reaction Acceleration.JACS Au · 2026Article
- Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Vesicles: a supramolecular tool to achieve organic reactions in aqueous media.Frontiers in chemistry · 2026Review
- Metabolism-based artificial organelles: From precise construction to smart theranostics.Materials today. Bio · 2025Review
- Dynamic Hydrogel-Based Cytomimetic Models for Chemical Information Conduction.Small science · 2025Article
- Dual-Stimulus Programmed Multiphase Separation and Organization in Coacervate Droplets.Angewandte Chemie (International ed. in English) · 2025Article
- Thermally Driven Dynamic Behaviors in Polymeric Vesicles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells.Small science · 2025Article
- Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications.Macromolecular bioscience · 2025Review
- A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction.Angewandte Chemie (International ed. in English) · 2025Article
- Photoreceptor-Like Signal Transduction Between Polymer-Based Protocells.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Peptide-Induced Division of Polymersomes for Biomimetic Compartmentalization.Angewandte Chemie (International ed. in English) · 2024Article
- Coacervate Droplets as Biomimetic Models for Designing Cell-Like Microreactors.Macromolecular rapid communications · 2024Review
- Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated Optoporation.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Recent Applications of Amphiphilic Copolymers in Drug Release Systems for Skin Treatment.Pharmaceutics · 2024Review
- Programmable Enzymatic Reaction Network in Artificial Cell-Like Polymersomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- pH-Responsive Elastin-Like Polypeptide Designer Condensates.ACS applied materials & interfaces · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living cells can spatiotemporally control biochemical reactions to dynamically assemble membraneless organelles and remodel cytoskeleton. Herein, we present a microfluidic approach to prepare semi-permeable polymersomes comprising of amphiphilic triblock copolymer to achieve external signal-driven complex coacervation as well as biophysical reconstitution of cytoskeleton within the polymersomes. We also show that the microfluidic synthesis of polymersomes enables precise control over size, efficient encapsulation of enzymes as well as regulation of substrates without the use of biopores. Moreover, we demonstrate that the resulting triblock copolymer-based membrane in polymersomes is size-selective, allowing phosphoenol pyruvate to readily diffuse through the membrane and induce enzymatic reaction and successive coacervation or actin polymerization in the presence of pyruvate kinase and adenosine diphosphate inside the polymersomes. We envision that the Pluronic-based polymersomes presented in this work will shed light in the design of in vitro enzymatic reactions in artificial cell-like vesicles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.