Evidence map›Paper›PMID 36055896›Full record

ReviewTrends in microbiology2023

Immune evasion strategies of major tick-transmitted bacterial pathogens.

Vipin Singh Rana, Chrysoula Kitsou, J Stephen Dumler, Utpal Pal

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vipin Singh RanaDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Chrysoula KitsouDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
J Stephen DumlerDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA. Electronic address: upal@umd.edu.
University of Maryland, College Park · USUniformed Services University of the Health Sciences · US

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
EHRLICHIA-GRANULOCYTE INTERACTIONS AND INFECTIONR01AI044102 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUMLER, JOHN STEPHEN · 2000 to 2019
$5.3M
BORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2M
BBA57-Mediated Borrelial Persistence, Genesis of Inflammation and ImmunityR01AI116620 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2015 to 2019
$1.9M
Function of selected vector-induced B. burgdorferi gene-productsR21AI076684 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2008 to 2009
$406k
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI044102NIAID NIH HHS R01 AI080615NIAID NIH HHS R01 AI116620NIAID NIH HHS R21 AI076684
6 · The paper itself

Abstract

Tick-transmitted bacterial pathogens thrive in enzootic infection cycles, colonizing disparate vertebrate and arthropod tissues, often establishing persistent infections. Therefore, the evolution of robust immune evasion strategies is central to their successful persistence or transmission between hosts. To survive in nature, these pathogens must counteract a broad range of microbicidal host responses that can be localized, tissue-specific, or systemic, including a mix of these responses at the host-vector interface. Herein, we review microbial immune evasion strategies focusing on Lyme disease spirochetes and rickettsial or tularemia agents as models for extracellular and intracellular tick-borne pathogens, respectively. A better understanding of these adaptive strategies could enrich our knowledge of the infection biology of relevant tick-borne diseases, contributing to the development of future preventions.

Indexed as

Borrelia burgdorferiIxodesRickettsiaTick-Borne DiseasesAnimalsHumansImmune EvasionAnaplasma phagocytophilumbacterial pathogensBorrelia burgdorferiimmune evasionticks

Identifiers

PMID36055896
PMCPMC9772108
OpenAlexW4293772991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.