Evidence map›Paper›PMID 36055521›Full record

ArticleMolecular and cellular neurosciences2022

Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)P

Xiong Li, Sangwoo Shim, Katherine R Hardin, Kiran G Vanaja, Hongjun Song, Andre Levchenko, Guo-Li Ming, James Q Zheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiong LiInstitute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Sangwoo ShimInstitute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.
Katherine R HardinDepartment of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.
Kiran G VanajaDepartment of Biomedical Engineering and Yale Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
Hongjun SongInstitute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
Andre LevchenkoDepartment of Biomedical Engineering and Yale Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
Guo-Li MingInstitute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
James Q ZhengDepartment of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA. Electronic address: james.zheng@emory.edu.
Emory University · USJohns Hopkins Medicine · USYale University · US

Funding

Systems analysis of phenotypic switch in control of cancer invasionU54CA209992 · NCI · YALE UNIVERSITY · PI LEVCHENKO, ANDRE · 2016 to 2021
$10.1M
Continuous Neurogenesis in the Mammalian HippocampusR35NS116843 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG · 2020 to 2026
$6.9M
Mechanisms of growth cone turning in diffusible gradientR01GM083889 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ZHENG, JAMES Q · 2007 to 2021
$4.5M
Calcium signaling in neuronal navigationR01NS048271 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2004 to 2014
$3.2M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
Neurobiology of MeCP2 in adult neurogenesisR01HD069184 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2010 to 2012
$734k
NCI NIH HHS U54 CA209992NICHD NIH HHS R01 HD069184NIGMS NIH HHS R01 GM083889NIGMS NIH HHS T32 GM135060NINDS NIH HHS R01 NS048271NINDS NIH HHS R35 NS116843
6 · The paper itself

Abstract

Axon guidance during neural wiring involves a series of precisely controlled chemotactic events by the motile axonal tip, the growth cone. A fundamental question is how neuronal growth cones make directional decisions in response to extremely shallow gradients of guidance cues with exquisite sensitivity. Here we report that nerve growth cones possess a signal amplification mechanism during gradient sensing process. In neuronal growth cones of Xenopus spinal neurons, phosphatidylinositol-3,4,5-trisphosphate (PIP

Indexed as

ActomyosinGrowth ConesBrain-Derived Neurotrophic FactorChemotaxisFeedbackActomyosinBrain-Derived Neurotrophic FactorActin cytoskeletonAsymmetric signalingAxon guidanceChemotaxisDirectional sensingPhosphoinositide

Identifiers

PMID36055521
PMCPMC9856701
OpenAlexW4293720758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.