ArticleCell2022
helixCAM: A platform for programmable cellular assembly in bacteria and human cells.
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Antibody Affinity Maturation by Yeast Mating against a Diverse Antigen Library Enhances Antibody Resistance to Viral Mutations.ACS pharmacology & translational science · 2026Article
- Mapping and engineering the human cell-cell interactome.Nature biotechnology · 2026Review
- De Novo Engineered Living Materials via Elastin-Like Polypeptide-Mediated Self-Assembly.ACS synthetic biology · 2026Article
- Synthetic circuits for cell ratio control.Nature · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Programming cellular condensates for living materials using an intrinsically disordered protein display platform.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Multiplexed polypeptide-based hybrid bacterial clusters by tailoring the conjugation for synergistic treatment of infected wounds.Materials today. Bio · 2025Article
- DNA-programmed responsive microorganism assembly with controlled patterns and behaviors.Science advances · 2025Article
- Designer mammalian living materials through genetic engineering.Bioactive materials · 2025Review
- Rapid and Controllable Multilayer Cell Sheet Assembly via Biodegradable Nanochannel Membranes.Advanced functional materials · 2025Article
- Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.Science advances · 2024Article
- The art of designed coiled-coils for the regulation of mammalian cells.Cell chemical biology · 2024Review
- A whole-cell platform for discovering synthetic cell adhesion molecules in bacteria.Nature communications · 2024Article
- Programming Spatial Cell Sorting by Engineering Cadherin Intracellular Activity.ACS synthetic biology · 2024Article
- Biophysical characterization of synthetic adhesins for predicting and tuning engineered living material properties.Matter · 2024Article
- Engineering pluripotent stem cells with synthetic biology for regenerative medicine.Medical review (2021) · 2024Review
- Designer cell therapy for tissue regeneration.Inflammation and regeneration · 2024Review
- Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Interactions between cells are indispensable for signaling and creating structure. The ability to direct precise cell-cell interactions would be powerful for engineering tissues, understanding signaling pathways, and directing immune cell targeting. In humans, intercellular interactions are mediated by cell adhesion molecules (CAMs). However, endogenous CAMs are natively expressed by many cells and tend to have cross-reactivity, making them unsuitable for programming specific interactions. Here, we showcase "helixCAM," a platform for engineering synthetic CAMs by presenting coiled-coil peptides on the cell surface. helixCAMs were able to create specific cell-cell interactions and direct patterned aggregate formation in bacteria and human cells. Based on coiled-coil interaction principles, we built a set of rationally designed helixCAM libraries, which led to the discovery of additional high-performance helixCAM pairs. We applied this helixCAM toolkit for various multicellular engineering applications, such as spherical layering, adherent cell targeting, and surface patterning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.