Evidence map›Paper›PMID 36055205›Full record

ArticleMolecular cell2022

SLC4A7 and mTORC1 raise nucleotide synthesis with bicarbonate.

Jessica C Koe, Keeley G Hewton, Seth J Parker

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Update on the relationship between theThe Journal of international medical research · 2023
    Pooled it
  2. Article
  3. Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jessica C KoeDepartment of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Keeley G HewtonDepartment of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Seth J ParkerDepartment of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC, Canada. Electronic address: seth.parker@bcchr.ca.
University of British Columbia · CABC Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue of Molecular Cell, Ali et al. (2022) show that bicarbonate uptake by SLC4A7 fuels de novo nucleotide synthesis and cell proliferation and is regulated by mTORC1.

Indexed as

BicarbonatesSodium-Bicarbonate SymportersCell ProliferationMechanistic Target of Rapamycin Complex 1NucleotidesBicarbonatesMechanistic Target of Rapamycin Complex 1NucleotidesSodium-Bicarbonate Symporters

Identifiers

PMID36055205
OpenAlexW4294190705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.