Evidence map›Paper›PMID 36054910›Full record

ArticleACS nano2022

Multiscale Modeling of Hepatitis B Virus Capsid Assembly and Its Dimorphism.

Farzaneh Mohajerani, Botond Tyukodi, Christopher J Schlicksup, Jodi A Hadden-Perilla, Adam Zlotnick, Michael F Hagan

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  7. Coarse-Graining Self-Assembly by the Stochastic Landscape Method.Journal of chemical theory and computation · 2025
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  10. Membrane bending energy selects for compact growth of protein assemblies.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Farzaneh MohajeraniMartin A. Fisher School of Physics, Brandeis University, Waltham, Massachusetts02453, United States.ORCID 0000-0002-9340-3305
Botond TyukodiMartin A. Fisher School of Physics, Brandeis University, Waltham, Massachusetts02453, United States.ORCID 0000-0001-6868-1234
Christopher J SchlicksupMolecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana47405, United States.
Jodi A Hadden-PerillaDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware19716, United States.ORCID 0000-0003-4685-8291
Adam ZlotnickMolecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana47405, United States.
Michael F HaganMartin A. Fisher School of Physics, Brandeis University, Waltham, Massachusetts02453, United States.ORCID 0000-0002-9211-2434
Brandeis University · USIndiana University Bloomington · USBabeș-Bolyai University · ROUniversity of Delaware · US

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Multimode Observation of Virus Capsid AssemblyR01AI118933 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI Adam Zlotnick · 2016 to 2026
$4.0M
Computational modeling of viral capsid and bacterial microcompartment assemblyR01GM108021 · NIGMS · BRANDEIS UNIVERSITY · PI HAGAN, MICHAEL F · 2013 to 2021
$2.7M
The Structural Biology of HBVR01AI144022 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI ZLOTNICK, ADAM · 2019 to 2022
$1.5M
Graduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926k
NIAID NIH HHS R01 AI118933NIAID NIH HHS R01 AI144022NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R01 GM108021NIGMS NIH HHS T32 GM109825
6 · The paper itself

Abstract

Hepatitis B virus (HBV) is an endemic, chronic virus that leads to 800000 deaths per year. Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies of a single protein. The capsid protein adopts different (quasi-equivalent) conformations to form icosahedral capsids containing 180 or 240 proteins:

Indexed as

CapsidHepatitis B virusAntiviral AgentsCapsid ProteinsSex CharacteristicsVirus AssemblyAntiviral AgentsCapsid Proteinsantiviralscomputational modelingHepatitis B virusmultiscale simulationsself-assemblyviral capsid

Identifiers

PMID36054910
PMCPMC10273259
OpenAlexW4294339123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.