ArticleJournal of veterinary internal medicine2022
Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Virological and pathological characterization of an outbreak of domestic cat hepatitis B virus infection in a cat shelter in Japan.The Journal of veterinary medical science · 2026Article
- Longitudinal observation of chronic domestic cat hepadnavirus infection in cats with evidence of extrahepatic involvement.Journal of feline medicine and surgery · 2025Article
- Pathological alteration and caspase-dependent activity of feline kidneys in natural infection of feline morbillivirus.BMC veterinary research · 2025Article
- Domestic cat hepadnavirus genotype B is present in Southern Brazil.Virus genes · 2025Article
- Domestic Cat Hepadnavirus Infection in Iberian Lynxes.Emerging infectious diseases · 2025Article
- Conserved Functions ofInternational journal of molecular sciences · 2024Article
- Domestic Cat Hepadnavirus Antigens in Lymphoma Tissues. Comment on Beatty et al. Domestic Cat Hepadnavirus and Lymphoma.Viruses · 2024Article
- Hepadnavirus Infection in a Cat with Chronic Liver Disease: A Multi-Disciplinary Diagnostic Approach.Veterinary sciences · 2023Article
- Article
- Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants.Pathogens (Basel, Switzerland) · 2023Review
- Article
- Quantification of domestic cat hepadnavirus DNA in various body fluid specimens of cats: the potential viral shedding routes.Frontiers in veterinary science · 2023Article
- Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study.Journal of veterinary internal medicine · 2022Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhether domestic cat hepadnavirus (DCH) infection is associated with clinical disease remains to be determined.
objectivesTo determine the relationship between DCH detection, hematology, serum bichemistry and liver histology in DCH-positive cats. ANIMALS: One thousand twenty-two cats in Thailand without concurrent diseases and not undergoing treatments adversely affecting the liver.
methodsRetrospective cross-sectional study. Samples derived from cats with concurrent virus detection were excluded. DCH detection was determined in blood and fresh-frozen liver by quantitative polymerase chain reaction (qPCR) and further investigated in liver sections showing histological parenchymal disorders (HPD) and normal liver (HNL) using in situ hybridization (ISH). Proliferative/apoptotic activities were determined using immunohistochemistry and ISH panels. Biochemical variables and risk factors for DCH infection were investigated.
resultsSix hundred sixty-one (557 blood and 119 liver samples) cats were included. DCH was detected in 18.50% (103/557), 13.85% (9/65), and 3.70% (2/54) of the blood, HPD, and HNL groups, respectively. Cats with DCH revealed abnormally high activity of aspartate aminotransferase (AST) (P = .001) and alanine aminotransferase (ALT) (P < .001). Among DCH-positive HPD case 2/9 an 7/9 were acute and chronic hepatitis, of which 4/7 had hepatitis. Log viral copy number (LVCN) was positively correlated with ALT (P < .001), triglyceride (P < .001), and gamma-glutamyl transpeptidase (GGT) (P = .022). The LVCN also had a positive association with degree of hepatitis (P < .05). There was hepatocyte proliferation activity in DHC positive cats. CONCLUSION AND CLINICAL IMPORTANCE: Domestic cat hepadnavirus infection was associated with high serum activity of liver enzymes and chronic lymphoplasmacytic hepatitis (LPH).
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