ArticleThoracic cancer2022
Dietary acid load and esophageal cancer risk: A case-control study.
Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The association of diet-dependent acid load with gastrointestinal cancer risk in the Cancer Screenee Cohort in Korea.European journal of clinical nutrition · 2025Article
- Relationship Between Dietary Acid Load and Risk of Metastatic Colorectal Cancer: A Case-Control Study.Current therapeutic research, clinical and experimental · 2025Article
- Dietary acid load decreases with age and is associated with sagittal abdominal diameter: a nationally representative quantification study in US adults.Aging clinical and experimental research · 2023Article
- Review
- The Impact of Plant-Based Diets on Dietary Acid Load Metrics in Venezuela: A Cross-Sectional Study.Nutrients · 2023Article
- How Well Do Low-PRAL Diets Fare in Comparison to the 2020-2025 Dietary Guidelines for Americans?Healthcare (Basel, Switzerland) · 2023Article
- Dietary acid load and esophageal cancer risk: A case-control study.Thoracic cancer · 2022Article
- Observational and clinical evidence that plant-based nutrition reduces dietary acid load.Journal of nutritional science · 2022Review
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high dietary acid load (DAL) can produce metabolic acidosis, which is linked to cancer development through mechanisms of inflammation and cell transformation. There is limited epidemiological evidence linking DAL and cancer risk; however, none of the published studies focused on DAL and esophageal cancer (EC) risk in particular. Therefore, we sought to explore this association in the present study.
methodsA case-control study was performed in 1295 male patients (185 squamous cell EC cases and 1110 age-frequency and urban/rural residence matched controls) through a multitopic inquiry, including a food frequency questionnaire. Food-derived nutrients were calculated from available databases. The DAL was calculated based on two validated measures: Potential renal acid load (PRAL) score and net endogenous acid production (NEAP) score. Odds ratios (OR) and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusting for confounders.
resultsWe found direct, significant associations between dietary acid load and EC risk: (OR = 2.28, 95% CI: 1.44-3.61, ptrend <0.0001) and (OR = 2.17, 95% CI: 1.38-3.41, ptrend <0.0001) for highest PRAL and NEAP tertiles, respectively. Our data raise the possibility that a high DAL may contribute to EC development. Both acid load scores were directly associated with animal-based foods (mainly meat) and inversely associated with the intake of plant-based foods.
conclusionTo the best of our knowledge, this is the first epidemiological case-control study analyzing associations of DAL and squamous cell EC risk. Further research is warranted to confirm our findings.
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