Evidence map›Paper›PMID 36054578›Full record

ArticlePediatric diabetes2022

Comorbidities increase COVID-19 hospitalization in young people with type 1 diabetes.

Elizabeth A Mann, Saketh Rompicherla, Mary Pat Gallagher, Guy Todd Alonso, Naomi R Fogel, Jill Simmons, Jamie R Wood, Jenise C Wong, Nudrat Noor, Patricia Gomez and 2 more

Open access · greenAbstract read
In one paragraph

Article in Pediatric diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.Journal of the Pediatric Infectious Diseases Society · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.medRxiv : the preprint server for health sciences · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 1 country.

Elizabeth A MannDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, UW Health Kids, Madison, Wisconsin, USA.ORCID 0000-0001-6439-0747
Saketh RompicherlaT1D Exchange, Boston, Massachusetts, USA.
Mary Pat GallagherDepartment of Pediatrics, NYU Langone, New York, New York, USA.
Guy Todd AlonsoDepartment of Pediatrics, University of Colorado, Barbara Davis Center, Aurora, Colorado, USA.ORCID 0000-0002-5676-761X
Naomi R FogelAnn & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jill SimmonsDepartment of Pediatrics, Vanderbilt Children Hospital, Nashville, Tennessee, USA.
Jamie R WoodDepartment of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA.
Jenise C WongDepartment of Pediatrics, University of California, San Francisco, California, USA.ORCID 0000-0003-0573-6650
Nudrat NoorT1D Exchange, Boston, Massachusetts, USA.
Patricia GomezDepartment of Pediatrics, University of Miami, Miami, Florida, USA.
Mark DanielsChildren Hospital of Orange County, Orange, California, USA.
Osagie EbekozienT1D Exchange, Boston, Massachusetts, USA.ORCID 0000-0002-8473-249X
T1D Exchange · USChildren's Hospital of Orange County · USMonroe Carell Jr. Children's Hospital · USNorthwestern University · USNYU Langone Health · USRainbow Babies & Children's Hospital · USUniversity of California, San Francisco · USUniversity of Colorado Denver · USUniversity of Miami · USUniversity of Mississippi · USUniversity of Wisconsin Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe evaluated COVID-19 outcomes in children and young adults with type 1 diabetes (T1D) to determine if those with comorbidities are more likely to experience severe COVID-19 compared to those without. RESEARCH DESIGN AND

methodsThis cross-sectional study included questionnaire data on patients <25 years of age with established T1D and laboratory-confirmed COVID-19 from 52 sites across the US between April 2020 and October 2021. We examined patient factors and COVID-19 outcomes between those with and without comorbidities. Multivariate logistic regression analysis examined the odds of hospitalization among groups, adjusting for age, HbA1c, race and ethnicity, insurance type and duration of diabetes.

resultsSix hundred fifty-one individuals with T1D and COVID-19 were analyzed with mean age 15.8 (SD 4.1) years. At least one comorbidity was present in 31%, and more than one in 10%. Obesity and asthma were the most frequently reported comorbidities, present in 19% and 17%, respectively. Hospitalization occurred in 17% of patients and 52% of hospitalized patients required ICU level care. Patients with at least one comorbidity were almost twice as likely to be hospitalized with COVID-19 than patients with no comorbidities (Odds ratio 2.0, 95% CI: 1.3-3.1). This relationship persisted after adjusting for age, HbA1c, race and ethnicity (minority vs nonminority), insurance type (public vs. private), and duration of diabetes.

conclusionsOur findings show that comorbidities increase the risk for hospitalization with COVID-19 in children and young adults highlighting the need for tailored COVID-19 prevention and treatment strategies in T1D.

Indexed as

COVID-19Diabetes Mellitus, Type 1AdolescentChildComorbidityCross-Sectional StudiesGlycated HemoglobinHospitalizationHumansSARS-CoV-2Young AdultGlycated HemoglobincomorbiditiesCOVID-19type 1 diabetes

Identifiers

PMID36054578
PMCPMC9538459
OpenAlexW4292103791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.