ArticleJournal of biomedical materials research. Part B, Applied biomaterials2023
In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Emerging Nanobiochar -Hydrogel Therapeutic Systems: Redox Modulation, Biointerface Interactions, and Critical Gaps in In Vitro Evaluation.Gels (Basel, Switzerland) · 2026Review
- Wireless flexible patch based on ultrasound-responsive SenA@ZIF-8 release for on-demand medication of periodontitis.Journal of nanobiotechnology · 2026Article
- Cytocompatibility Assessment of L-PBF-Manufactured Zinc-Silver-Copper Alloys for Customized Biodegradable Medical Implants.Journal of functional biomaterials · 2026Article
- Article
- Experimental investigation on enhancing the mechanical properties of biodegradable Zn-3Mg alloys reinforced with snail-shell particulates via powder metallurgy.Journal of materials science. Materials in medicine · 2025Article
- ZnO and ZnS Hybrid Film Enhances the Bone Regeneration Performance of Zinc-Based Implants.ACS omega · 2025Article
- Machine learning-based optimization of cytotoxicity testing for assessing Zn-based biodegradable metals.Materials today. Bio · 2025Article
- Divalent metal ions enhance bone regeneration through modulation of nervous systems and metabolic pathways.Bioactive materials · 2025Article
- Mucin Coatings Establish Multifunctional Properties on Commercial Sutures.ACS applied bio materials · 2025Article
- Development of Novel Biocomposites with Antimicrobial-Activity-Based Magnesium-Doped Hydroxyapatite with Amoxicillin.Antibiotics (Basel, Switzerland) · 2024Article
- Review
- Therapeutic coordination polymers: tailoring drug release through metal-ligand interactions.Chemical science · 2024Article
- 3D Printing of a Porous Zn-1Mg-0.1Sr Alloy Scaffold: A Study on Mechanical Properties, Degradability, and Biosafety.Journal of functional biomaterials · 2024Article
- Biocompatibility Assessment of Zinc Alloys as a New Potential Material for Bioabsorbable Implants for Osteosynthesis.Materials (Basel, Switzerland) · 2023Article
- Development, Processing and Aging of Novel Zn-Ag-Cu Based Biodegradable Alloys.Materials (Basel, Switzerland) · 2023Article
- Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review.Journal of functional biomaterials · 2023Review
- In vitro cytocompatibility and antibacterial studies on biodegradable Zn alloys supplemented by a critical assessment of direct contact cytotoxicity assay.Journal of biomedical materials research. Part B, Applied biomaterials · 2023Article
- Recent Developments in Zn-Based Biodegradable Materials for Biomedical Applications.Journal of functional biomaterials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro cytotoxicity assessment is indispensable in developing new biodegradable implant materials. Zn, which demonstrates an ideal corrosion rate between Mg- and Fe-based alloys, has been reported to have excellent in vivo biocompatibility. Therefore, modifications aimed at improving Zn's mechanical properties should not degrade its biological response. As sufficient strength, ductility and corrosion behavior required of load-bearing implants has been obtained in plastically deformed Zn-3Ag-0.5Mg, the effect of simultaneous Ag and Mg additions on in vitro cytocompatibility and antibacterial properties was studied, in relation to Zn and Zn-3Ag. Direct cell culture on samples and indirect extract-based tests showed almost no significant differences between the tested Zn-based materials. The diluted extracts of Zn, Zn-3Ag, and Zn-3Ag-0.5Mg showed no cytotoxicity toward MG-63 cells at a concentration of ≤12.5%. The cytotoxic effect was observed only at high Zn
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.