Evidence map›Paper›PMID 36054347›Full record

Observational studyThe Journal of clinical endocrinology and metabolism2022

The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia-Subanalysis of the DALI Study.

Delia Bogdanet, Miguel Angel Luque-Fernandez, Michelle Toth-Castillo, Gernot Desoye, Paula M O'Shea, Fidelma P Dunne, Jose A Halperin

Erratum issuedOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Delia BogdanetCollege of Medicine, Nursing and Health Sciences, School of Medicine, National University of Ireland, Galway H91TK33, Ireland.ORCID 0000-0001-6127-5049
Miguel Angel Luque-FernandezDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Michelle Toth-CastilloDivision of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gernot DesoyeDepartment of Obstetrics and Gynecology, Medizinische Universitaet Graz, Graz A8036, Austria.
Paula M O'SheaCollege of Medicine, Nursing and Health Sciences, School of Medicine, National University of Ireland, Galway H91TK33, Ireland.
Fidelma P DunneCollege of Medicine, Nursing and Health Sciences, School of Medicine, National University of Ireland, Galway H91TK33, Ireland.
Jose A HalperinDivision of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ollscoil na Gaillimhe – University of Galway · IEBrigham and Women's Hospital · USHarvard University · USMedical University of Graz · AT

Funding

Human Studies on Blood Levels of Glycated CD59 as a Biomarker in DiabetesR01DK101442 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HALPERIN, JOSE A · 2014 to 2018
$3.5M
Blood Levels of Glycated CD59, a Novel Biomarker to Assess Pregnancy-induced Glucose IntoleranceR01DK118528 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HALPERIN, JOSE A · 2019 to 2023
$3.5M
Glycated CD59 as a novel biomarker of gestational diabetes mellitusR21DK095429 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HALPERIN, JOSE A · 2012 to 2013
$460k
Glycated CD59 as a Biomarker for DiabetesR56DK089206 · NIDDK · HARVARD MEDICAL SCHOOL · PI HALPERIN, JOSE A · 2010 to 2010
$254k
European Community's Seventh Framework Programme 242187NIDDK NIH HHS R01 DK101442NIDDK NIH HHS R01 DK118528NIDDK NIH HHS R21 DK095429NIDDK NIH HHS R56 DK089206NIH HHS DK095424
6 · The paper itself

Abstract

contextNeonatal hypoglycaemia (NH) is the most common metabolic problem in infants born of mothers with gestational diabetes. Plasma glycated CD59 (pGCD59) is an emerging biomarker that has shown potential in identifying women at risk of developing gestational diabetes. The aim of this study was to assess the association between early maternal levels of pGCD59 and NH.

objectiveThe aim of this study was to assess the association between early pregnancy maternal levels of plasma glycated CD59 (pGCD59) and neonatal hypoglycemia (NH).

methodsThis is an observational study of pregnant women with a prepregnancy body mass index (BMI) greater than or equal to 29 screened for eligibility to participate in the Vitamin D and Lifestyle Intervention for Gestational Diabetes (DALI) trial. This analysis included 399 pregnancies. Levels of pGCD59 were measured in fasting maternal samples taken at the time of a 75-g, 2-hour oral glucose tolerance test performed in early pregnancy (< 20 weeks). NH, the study outcome, was defined as a heel-prick capillary glucose level of less than 2.6 mmol/L within 48 hours of delivery.

resultsWe identified 30 infants with NH. Maternal levels of pGCD59 in early pregnancy were positively associated with the prevalence of NH (one-way analysis of variance, P < .001). The odds of NH were higher in infants from mothers in tertile 3 of pGCD59 levels compared to those from mothers in tertile 1 (odds ratio [OR]: 2.41; 95% CI, 1.03-5.63). However, this was attenuated when adjusted for maternal BMI (OR: 2.28; 95% CI, 0.96-5.43). The cross-validated area under the curve (AUC) was 0.64 (95% CI, 0.54-0.74), and adjusted for maternal BMI, age, and ethnicity, the AUC was 0.70 (95% CI, 0.56-0.78).

conclusionAlthough pGCD59 levels in early pregnancy in women with BMI greater than or equal to 29 are associated with NH, our results indicate that this biomarker by itself is only a fair predictor of NH.

Indexed as

Diabetes, GestationalFetal DiseasesHypoglycemiaInfant, Newborn, DiseasesBiomarkersBlood GlucoseFemaleGlucose Tolerance TestHumansInfantInfant, NewbornPregnancyBiomarkersBlood Glucosebiomarkersepidemiologyglycationneonatal hypoglycemiaprediction

Identifiers

PMID36054347
PMCPMC9681607
OpenAlexW4294295636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.