Evidence map›Paper›PMID 36054308›Full record

ArticleEuropean journal of haematology2022

Clonal haematopoiesis of indeterminate potential and impaired kidney function-A Danish general population study with 11 years follow-up.

Morten K Larsen, Vibe Skov, Lasse Kjaer, Natascha A Møller-Palacino, Rasmus K Pedersen, Morten Andersen, Johnny T Ottesen, Sabrina Cordua, Henrik E Poulsen, Morten Dahl and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of haematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  7. Hemoglobin-associatedFrontiers in medicine · 2025
    Article
  8. Review
  9. Clonal haematopoiesis, ageing and kidney disease.Nature reviews. Nephrology · 2024
    Review
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Morten K LarsenDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0002-2873-5928
Vibe SkovDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0003-0097-7826
Lasse KjaerDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0001-6767-0226
Natascha A Møller-PalacinoDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.
Rasmus K PedersenDepartment of Science and Environment, Roskilde University, Roskilde, Denmark.
Morten AndersenDepartment of Science and Environment, Roskilde University, Roskilde, Denmark.
Johnny T OttesenDepartment of Science and Environment, Roskilde University, Roskilde, Denmark.
Sabrina CorduaDepartment of Haematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Henrik E PoulsenDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten DahlDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Trine A KnudsenDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.
Christina Schjellerup Eickhardt-DalbøgeDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.
Steffen KoschmiederDepartment of Haematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-1011-8171
Kasper M PedersenDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yunus ÇolakDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stig E BojesenDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4061-4133
Børge G NordestgaardDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thomas StiehlDepartment of Science and Environment, Roskilde University, Roskilde, Denmark.
Hans C HasselbalchDepartment of Haematology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0003-3936-8032
Christina EllervikDepartment Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-3088-4375
University of Copenhagen · DKRoskilde University · DKZealand University Hospital · DKCopenhagen University Hospital · DKRWTH Aachen University · DE

Funding

Aase and Ejnar Danielsen's FoundationAnders Hasselbalch's Foundation Fighting LeukemiaA.V. Lykfeldt and Wife's ScholarshipCandys FoundationCarpenter Joergen Holm and Wife Elisa F. Hansen's Memorial FoundationDagmar Marshalls FondElse and Mogens Wedell-Wedellborgs FoundationEva and Henry Fraenkels Memorial FoundationJohan and Lise Boserup FoundationJohannes Fog's FoundationManufacturer Einar Willumsens Memorial FoundationNaestved HospitalNaestved Hospital FoundationNaestved MunicipalityRegion ZealandThe Hoejmosegaard ScholarshipThe Local Government Denmark FoundationThe Lundbeck Foundation FellowshipThe National Board of HealthThe Region Zealand Research FoundationTrygFonden
6 · The paper itself

Abstract

The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F (N = 613) or CALR (N = 32) mutations. Mutation-positive individuals without haematological malignancy were defined as having CHIP (N = 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml/min/1.73 m

Indexed as

CalreticulinThrombocythemia, EssentialClonal HematopoiesisDenmarkFollow-Up StudiesHumansJanus Kinase 2KidneyMutationCalreticulinJanus Kinase 2CALRCHIPclonal haematopoiesis of indeterminate potentialeGFRepidemiologyimpaired kidney functionJAK2V617Fpopulation studies

Identifiers

PMID36054308
PMCPMC9804367
OpenAlexW4290840280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.