Evidence map›Paper›PMID 36054205›Full record

ArticlePloS one2022

Lipid lowering therapy patterns and the risk of cardiovascular events in the 1-year after acute myocardial infarction in United Arab Emirates.

Lionel Pinto, Mohamed Farghaly, Sasikiran Nunna, Badarinath Chickballapur Ramachandrachar, Sri Harshadeep Chilukuri, Ashok Natarajan

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lionel PintoAmgen Inc., One Amgen Drive, Thousand Oaks, California, United States of America.
Mohamed FarghalyDubai Health Authority, Dubai, United Arab Emirates.
Sasikiran NunnaIQVIA, Plymouth Meeting, Pennsylvania, United States of America.
Badarinath Chickballapur RamachandracharIQVIA, Dubai World Trade Centre, Dubai, United Arab Emirates.ORCID 0000-0001-9965-1492
Sri Harshadeep ChilukuriIQVIA, Dubai World Trade Centre, Dubai, United Arab Emirates.
Ashok NatarajanIQVIA, Dubai World Trade Centre, Dubai, United Arab Emirates.ORCID 0000-0001-9435-1300
Amgen (United States) · USDubai Health Authority · AEIQVIA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimIn United Arab Emirates, cardiovascular disease (CVD) is a leading cause of mortality and 22% of CVD deaths are attributable to acute myocardial infarction (MI). Adherence to guidelines for lipid management is incompletely described in the Middle East. This study aimed to characterize lipid lowering therapy (LLT) patterns and the risk of subsequent cardiovascular events (CVEs) in the first year after MI.

methodsThis was a retrospective cohort study using the Dubai Real-World Claims Database, including all patients discharged with MI between January 01, 2015 and December 31, 2018, followed-up until December 31, 2019.

resultsIn the first year after MI, 8.42% of 4,595 patients included experienced at least one recurrent MI (rate 6.77 events/100 person-years [PYs]), 2.94% had one revascularization (cumulative rate 0.55 events/100 PYs) and 2.66% had one hospitalization due to unstable angina (cumulative rate 5.16 new events/100 PYs). The majority (60.40%) of the patients presented with LDL-C levels ≥ 70 mg/dL after MI. In the first year after MI, 93.45% of the patients received LLT, mainly high-intensity statin (67.79%); with a minority of patients receiving statin + ezetimibe (4.55%), PCSK9i (0.20%) or ezetimibe alone (0.07%).

conclusionPatients hospitalized with MI in Dubai present an increased risk of CVEs in their first-year post-discharge. Majority of the patients presented with LDL-C levels above 70 mg/dL, which indicates suboptimal lipid control with existing LLT, particularly in high-risk patients.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsMyocardial InfarctionAftercareCholesterol, LDLEzetimibeHumansPatient DischargeRetrospective StudiesUnited Arab EmiratesCholesterol, LDLEzetimibeHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID36054205
PMCPMC9439245
OpenAlexW4294295849

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.