ArticlePloS one2022
The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The myodural bridge complex: a comprehensive review of morphology, physiology, developmental biology and pathology.Frontiers in medicine · 2026Review
- Identification, structural features, and potential functional significance of the myodural Bridge in African clawed frog, the Xenopus laevis.Scientific reports · 2025Article
- Temporal and spatial variations in CSF pressure are influenced by electrical stimulation of the OCI muscles in beagles.Scientific reports · 2025Article
- Denervation of rectus capitis posterior minor as neglected factor in Chiari malformation type I revealed by double blinded prospective study.Scientific reports · 2025Article
- Force-dependent development of the myodural bridge in rats: The impact of Integrin α7.PloS one · 2025Article
- The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats.Frontiers in cell and developmental biology · 2025Article
- Intracranial pressure and pulsatility in different head and body positions.Brain communications · 2025Article
- Resveratrol ameliorates pathological fibrosis of the myodural bridge by regulating the SIRT3/TGF-β1/Smad pathway.Heliyon · 2024Article
- Comparative genomic studies on the TGF-β superfamily in blue whale.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Neuraxial biomechanics, fluid dynamics, and myodural regulation: rethinking management of hypermobility and CNS disorders.Frontiers in neurology · 2024Review
- The relationship between myodural bridge, atrophy and hyperplasia of the suboccipital musculature, and cerebrospinal fluid dynamics.Scientific reports · 2023Article
- The growth and developmental of the myodural bridge and its associated structures in the human fetus.Scientific reports · 2023Article
- Myostatin: a potential therapeutic target for metabolic syndrome.Frontiers in endocrinology · 2023Review
- The Influence of Movement on the Cerebrospinal Fluid Pressure of the American Alligator (Biology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics.
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