ArticleJournal of the American Geriatrics Society2022
Frailty and affective disorders throughout adult life: A 5-year follow-up of the Lifelines Cohort Study.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Anxiety, life-space mobility and quality of life among frail older adults in Enugu, South-East Nigeria.BMC public health · 2026Article
- The association of depressive symptoms and dietary inflammatory index with frailty in older adults with diabetes.BMC psychiatry · 2026Article
- The Mediating Role of Frailty in Healthcare Utilization Among Sexual and Gender Minorities: A Comparison of Generalist, Specialist, and Mental Health Visits.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Article
- Exploring the relationship between sleep quality, anxiety, depression and frailty in older adults with stroke: a latent profile and mediation analysis.BMC geriatrics · 2025Article
- On the edge of dependency: how older adults with rheumatoid arthritis experience living with frailty.EULAR rheumatology open · 2025Article
- Social participation and insomnia in Chinese older adults with multimorbidity: mediating roles of frailty, anxiety, and depression.BMC geriatrics · 2025Article
- Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study.BJPsych open · 2025Article
- Predictive features analysis and nomogram construction for predicting depression in elderly patients.Frontiers in psychology · 2025Article
- Psychological states mediate the relationship between sleep quality and frailty among older adults.Frontiers in psychology · 2025Article
- Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.BMC psychiatry · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Bidirectional causal relational between frailty and mental illness: a two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Association of frailty with cognitive impairment and functional disability in older adults with affective disorders: a brief research report.Frontiers in psychiatry · 2023Article
- Interaction effects of anxiety and outdoor activity spaces on frailty among nursing home residents in Jinan, China: Is there a gender difference?Frontiers in public health · 2023Article
- Frailty and affective disorders throughout adult life: A 5-year follow-up of the Lifelines Cohort Study.Journal of the American Geriatrics Society · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is an important concept for risk stratification in clinical practice, but it is hardly acknowledged at all in mental healthcare settings. This paper aims to assess the impact of frailty on the course of depression and anxiety, and the impact of these affective disorders on the course of frailty.
methodsLifelines, a prospective population-based cohort study, evaluated 167,729 people living in the northern Netherlands. Frailty was based on the deficit accumulation model, which resulted in a 60-item frailty index (FI) at baseline and a 35-item FI at baseline and 5-year follow-up. Current depressive and anxiety disorders were assessed with the Mini International Neuropsychiatric Interview according to DSM-IV criteria. Bidirectional associations between frailty and affective disorders were investigated using separate multivariable regression analyses in younger (<60 years) and older adults (≥60 years).
resultsThe FI was associated with the onset of a depressive disorder (younger adults: odds ratio [OR] = 1.12; 95% confidence interval [CI] 1.11-1.13; older adults: OR = 1.13; 95% CI 1.09-1.16) as well as any anxiety disorder (younger adults: OR = 1.10; 95% CI 1.09-1.10; older adults: OR = 1.07; 95% CI 1.04-1.09). The other way around, depressive disorder and anxiety disorders were associated with an accelerated increase of frailty over time (depressive disorder: younger adults: beta [β] = 0.03, p < 0.001; older adults: β = 0.04, p < 0.001; and any anxiety disorder: younger adults: β = 0.02, p < 0.001; older adults: β = 0.01, p < 0.142), although the effect of anxiety disorders was less equivocal among older adults.
conclusionsAffective disorders are reciprocally related to frailty. Results with respect to the impact of anxiety disorders on frailty suggest most impact at lower levels of frailty. Our results might imply that interventions to slow biological aging should be broadened towards younger and middle-aged people as well as non-frail older patients. To develop targeted treatment, future clinical and epidemiologic studies on the underlying pathways of this bidirectional association are needed.
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