Evidence map›Paper›PMID 36053924›Full record

ArticleAutism research : official journal of the International Society for Autism Research2022

Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits.

Ido Shalev, Varun Warrier, David M Greenberg, Paula Smith, Carrie Allison, Simon Baron-Cohen, Alal Eran, Florina Uzefovsky

Open access · hybridAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Pooled it
  2. Trial
  3. Navigating Mixed-Neurotype Dialogue: Environmental and Affective Influences on Autistic Speakers.Autism : the international journal of research and practice · 2026
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  12. 'Behavioral sciences (Basel, Switzerland) · 2025
    Article
  13. 'American journal of sexuality education · 2024
    Article
  14. The world is nuanced but pixelated: Autistic individuals' perspective on HIPPEA.Autism : the international journal of research and practice · 2024
    Article
  15. Prevalence of bias against neurodivergence-related terms in artificial intelligence language models.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  16. Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023
    Review
  17. Article
  18. Article
  19. Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ido ShalevPsychology Department, Ben Gurion University of the Negev, Beer-Sheba, Israel.ORCID 0000-0002-2034-4527
Varun WarrierDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
David M GreenbergDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Paula SmithDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Carrie AllisonDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Simon Baron-CohenDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
Alal EranZlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer-Sheba, Israel.
Florina UzefovskyPsychology Department, Ben Gurion University of the Negev, Beer-Sheba, Israel.ORCID 0000-0003-4571-2514
University of Cambridge · GBBen-Gurion University of the Negev · ILBar-Ilan University · IL

Funding

Department of HealthMedical Research CouncilWellcome TrustWellcome Trust 214322\Z\18\Z
6 · The paper itself

Abstract

A large body of research showed that autistic people have intact emotional (affective) empathy alongside reduced cognitive empathy. However, there are mixed findings and these call for a more subtle understanding of empathy in autism. Empathic disequilibrium refers to the imbalance between emotional and cognitive empathy and is associated with a higher number of autistic traits in the typical population. Here we examined whether empathic disequilibrium predicts both the number of autistic traits and autism diagnosis. In a large sample of autistic (N = 1905) and typical individuals (N = 3009), we examined empathic disequilibrium and empathy as predictors of autistic traits and autism diagnosis, using a polynomial regression with response surface analysis. Empathy and autistic traits were measured using validated self-report questionnaires. Both empathic disequilibrium and empathy predicted linearly and non-linearly autism diagnosis and autistic traits. Specifically, a tendency towards higher emotional than cognitive empathy (empathic disequilibrium towards emotional empathy) predicted both autism diagnosis and the social domain of autistic traits, while higher cognitive than emotional empathy was associated with the non-social domain of autism. Empathic disequilibrium was also more prominent in autistic females. This study provides evidence that beyond empathy as was measured thus far, empathic disequilibrium offers a novel analytical approach for examining the role of empathy. Empathic disequilibrium allows for a more nuanced understanding of the links between empathy and autism. LAY SUMMARY: Many autistic individuals report feelings of excessive empathy, yet their experience is not reflected by most of the current literature, typically suggesting that autism is characterized by intact emotional and reduced cognitive empathy. To fill this gap, we looked at both ends of the imbalance between these components, termed empathic disequilibrium. We show that, like empathy, empathic disequilibrium is related to autism diagnosis and traits, and thus may provide a more nuanced understanding of empathy and its link with autism.

Indexed as

Autism Spectrum DisorderAutistic DisorderEmpathyFemaleHumansPhenotypeSurveys and Questionnairesautismcognitiveemotional empathyempathyresponse surface analysis

Identifiers

PMID36053924
PMCPMC9804307
OpenAlexW4294090763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.