Evidence map›Paper›PMID 36053869›Full record

ArticleBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology2022

From genetics to biotechnology: Synthetic biology as a flexible course-embedded research experience.

Kristen C Johnson, Jaime L Sabel, Judith Cole, Christin L Pruett, Ruth Plymale, Nathan S Reyna

Abstract read
In one paragraph

Article in Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Biochemistry Learning in Higher Education: A Systematic Review on Methodologies and Teaching Resources.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
    Pooled it
  2. Comparative Investigations of the Neurophysiological Mechanisms of Escape Behavior: A Course-based Undergraduate Research Experience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. From genetics to biotechnology: Synthetic biology as a flexible course-embedded research experience.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristen C JohnsonDepartment of Life Sciences, University of New Hampshire, Manchester, New Hampshire, USA.ORCID 0000-0002-1825-0265
Jaime L SabelDepartment of Biological Sciences, University of Memphis, Memphis, Tennessee, USA.
Judith ColeDepartment of Biological Sciences, University of Memphis, Memphis, Tennessee, USA.
Christin L PruettDepartment of Biology, Ouachita Baptist University, Arkadelphia, Arkansas, USA.
Ruth PlymaleDepartment of Biology, Ouachita Baptist University, Arkadelphia, Arkansas, USA.
Nathan S ReynaDepartment of Biology, Ouachita Baptist University, Arkadelphia, Arkansas, USA.

Funding

Ultrastructural analysis of axonal Kv2-mediated endoplasmic reticulum/plasma membrane (ER/PM) junctionsP20GM103506 · NIGMS · DARTMOUTH COLLEGE · PI Yina Hsing Huang · 2012 to 2026
$60.1M
Arkansas EPSCoR Program, ASSET III and by the Cell Biology Education Consortium, an NSF-RCN-UBE 1827066Center for Advanced Surface Engineering under the United States National Science Foundation IIA-1457888NIGMS NIH HHS P20 GM103506University of Memphis Technology Access Fee (TAF) Equipment grant
6 · The paper itself

Abstract

The need for changing how science is taught and the expansion of undergraduate research experiences is essential to foster critical thinking in the Natural Sciences. Most faculty research programs only involve a small number of upper-level undergraduate students each semester. The course-based undergraduate research experience (CURE) model enables more students to take ownership over an independent project and experience authentic research. Further, by creating projects that fit into a curriculum's learning goals and student-oriented outcomes, departments help strengthen critical thinking skills in the classroom. Here, we report on the incorporation of a synthetic biology CURE into a mid-level cellular biology course and two advanced level genetics/molecular biology courses. Synthetic biology involves systematic engineering of novel organisms, such as bacteria and plants, to work as functional devices to solve problems in medicine, agriculture, and manufacturing. The value of synthetic biology and its ultimate utility as a teaching tool relies on reusable, standard genetic parts that can be interchanged using common genetic engineering principles. This Synthetic biology CURE effectively achieves five essential goals: (1) a sense of project ownership; (2) self-efficacy: mastery of a manageable number of techniques; (3) increased tolerance for obstacles through challenging research; (4) increased communication skills; and (5) a sense of belonging in a larger scientific community. Based upon our student assessment data, we demonstrate that this course-based synthetic biology laboratory engages students directly in an authentic research experience and models important elements of collaboration, discovery, iteration, and critical thinking.

Indexed as

CurriculumSynthetic BiologyBiologyEngineeringHumansStudentsThinkingcourse-based undergraduate research experienceCUREsynthetic biology

Identifiers

PMID36053869
PMCPMC9826443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.