Evidence map›Paper›PMID 36053839›Full record

ArticleInternational journal of cancer2023

Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).

Yahya Mahamat-Saleh, Marie Al-Rahmoun, Gianluca Severi, Reza Ghiasvand, Marit B Veierod, Saverio Caini, Domenico Palli, Edoardo Botteri, Carlotta Sacerdote, Fulvio Ricceri and 27 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Review
  6. DownregulatedCells · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 11 countries.

Yahya Mahamat-SalehParis-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.
Marie Al-RahmounParis-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.
Gianluca SeveriParis-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.
Reza GhiasvandOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-5466-7308
Marit B VeierodOslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Saverio CainiCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Edoardo BotteriDepartment of Research, Cancer Registry of Norway, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-9023-8068
Carlotta SacerdotePiedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin, Italy.ORCID 0000-0002-8008-5096
Fulvio RicceriEpidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, Italy.ORCID 0000-0001-8749-9737
Marko LukicFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Norway.ORCID 0000-0002-3608-9743
Maria J SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain.
Valeria PalaEpidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0001-5438-970X
Rosario TuminoHyblean Association for Epidemiological Research AIRE-ONLUS, Ragusa, Italy.
Paolo ChiodiniDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.
Pilar AmianoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Sandra Colorado-YoharCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
María-Dolores ChirlaqueCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Eva ArdanazCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Catalina BonetUnit of Nutrition and Cancer, Catalan Institute of Oncology-ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-(IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Kim OvervadDepartment of Public Health, Aarhus University, Aarhus C, Denmark.
Christina C DahmDepartment of Public Health, Aarhus University, Aarhus C, Denmark.
Christian S AntoniussenDepartment of Public Health, Aarhus University, Aarhus C, Denmark.
Anne TjønnelandDanish Cancer Society Research Center; Diet, Genes and Environment Nutrition and Biomarkers (NAB), Copenhagen, Denmark.
Cecilie KyrøCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.ORCID 0000-0002-9083-8960
Bas Bueno-de-MesquitaCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Jonas ManjerDepartment of Surgery, Skåne University Hospital Malmö Lund University Malmö, Malmö, Sweden.ORCID 0000-0002-3158-5289
Malin JanssonDepartment of Surgery and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.
Anders EsbergDepartment of Odontology, Umeå University, Umeå, Sweden.
Nagisa MoriInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-1721-4083
Pietro FerrariInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0001-9358-7338
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-2237-0128
Marie-Christine Boutron-RuaultParis-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.ORCID 0000-0002-5956-5693
Marina KvaskoffParis-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.ORCID 0000-0002-4557-3772
Inserm · FRAarhus University · DKCentre international de recherche sur le cancer · FRGerman Cancer Research Center · DENational Institute for Public Health and the Environment · NLOslo University Hospital · NOPrevention Institute · USUmeå University · SEBasque Government · ESBitron (Italy) · ITDanish Cancer Society · DKFondazione IRCCS Istituto Nazionale dei Tumori · ITInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESItalian Association for Cancer Research · ITLund University · SEPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUiT The Arctic University of Norway · NOUniversidad de Antioquia · CO

Funding

British Heart FoundationCancer Research UK 14136Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Department of HealthMedical Research Council 1000143Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; P

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellMelanomaSkin NeoplasmsAlcohol DrinkingFemaleHumansMaleProspective StudiesRisk Factorsalcoholcohort studiescutaneous melanomaepidemiologykeratinocyte cancers

Identifiers

PMID36053839
PMCPMC10087036
OpenAlexW4292372541

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.