Evidence map›Paper›PMID 36053833›Full record

ArticleThe journal of physical chemistry. B2022

Exploring Structural Flexibility and Stability of α-Synuclein by the Landau-Ginzburg-Wilson Approach.

Anatolii Korneev, Alexander Begun, Sergei Liubimov, Khatuna Kachlishvili, Alexander Molochkov, Antti J Niemi, Gia G Maisuradze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anatolii KorneevPacific Quantum Center, Far Eastern Federal University, 690922, Vladivostok, Russia.
Alexander BegunPacific Quantum Center, Far Eastern Federal University, 690922, Vladivostok, Russia.
Sergei LiubimovPacific Quantum Center, Far Eastern Federal University, 690922, Vladivostok, Russia.
Khatuna KachlishviliBaker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, United States.
Alexander MolochkovPacific Quantum Center, Far Eastern Federal University, 690922, Vladivostok, Russia.
Antti J NiemiPacific Quantum Center, Far Eastern Federal University, 690922, Vladivostok, Russia.
Gia G MaisuradzeBaker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, United States.ORCID 0000-0002-1901-8433

Funding

INTERNAL BONDIN IN PROTEINSR01GM014312 · NIGMS · CORNELL UNIVERSITY ITHACA · PI MAISURADZE, GIA, RACKOVSKY, SHALOM R · 1985 to 2021
$9.4M
NIGMS NIH HHS R01 GM014312
6 · The paper itself

Abstract

α-Synuclein (αS) is the principal protein component of the Lewy body and Lewy neurite deposits that are found in the brains of the victims of one of the most prevalent neurodegenerative disorders, Parkinson's disease. αS can be qualified as a chameleon protein because of the large number of different conformations that it is able to adopt: it is disordered under physiological conditions in solution, in equilibrium with a minor α-helical tetrameric form in the cytoplasm, and is α-helical when bound to a cell membrane. Also,

Indexed as

alpha-SynucleinParkinson DiseaseAmyloidBrainHumansMolecular Dynamics Simulationalpha-SynucleinAmyloid

Identifiers

PMID36053833
PMCPMC9482328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.