ArticleJournal of behavioral addictions2022
Sex differences in neural substrates of risk taking: Implications for sex-specific vulnerabilities to internet gaming disorder.
Article in Journal of behavioral addictions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Altered long-range temporal correlations in delta oscillatory amplitude dynamics in gambling disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder.Annals of general psychiatry · 2026Article
- The role of ovarian hormones in risk aversion in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Parenting styles and freshman's internet gaming disorder: a moderated chain mediation model involving presence of meaning in life and self-control.Frontiers in psychology · 2026Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Mediating role of depression and gender in the relationship between daily video games exposure and internet gaming disorder (IGD) among college students.BMC psychology · 2025Article
- Altered dynamic reconfiguration of brain functional networks during gaming and deprivation in individuals with internet gaming disorder.Journal of behavioral addictions · 2025Article
- Sex differences in brain-behavior relationships in the first 2 years of life.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Facial Emotional Expression in Reaction to Internet Gaming Videos Among Young Adults: A Preliminary and Exploratory Study.Neuropsychopharmacology reports · 2025Article
- Gender differences in problematic gaming among Chinese adolescents and young adults.BMC psychiatry · 2025Article
- Wanting-liking dissociation and altered dopaminergic functioning: Similarities between internet gaming disorder and tobacco use disorder.Journal of behavioral addictions · 2024Article
- Explicit and implicit effects of gaming content on social media on the behavior of young adults.Frontiers in psychology · 2024Article
- Sex differences of neural connectivity in internet gaming disorder and its association with sleep quality: an exploratory fMRI study.Frontiers in psychiatry · 2024Article
- A systematic review of sex/gender differences in the multi-dimensional neurobiological mechanisms in addiction and their relevance to impulsivity.Current addiction reports · 2023Article
- Impulsivity-related right superior frontal gyrus as a biomarker of internet gaming disorder.General psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Sex differences in internet gaming disorder (IGD) remain unknown. Investigating sex-specific neural features that underlie the core risk factor (i.e., risk-taking) of IGD would help in understanding sex-specific vulnerabilities to IGD and advance sex-specific treatments and prevention for IGD. Methods: 111 participants (28 IGD males, 27 IGD females, 26 recreational game user (RGU) males, 30 RGU females) completed a probability discounting task during fMRI scanning. Results: First, among RGUs, males showed a higher risk-taking tendency and greater neural activation associated with risk/value evaluation for reward (the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), left putamen) and smaller activation associated with cognitive control (the inferior frontal gyrus) than females during the contrast of risky-safe choices. Moreover, males showed a greater modulatory effect of risky choices on the connection from the vmPFC/ACC to the left putamen than females. Second, IGD males showed decreased activation in the vmPFC/ACC and left putamen compared to RGU males, whereas this decrease did not exist in IGD females. Discussion: Males show a higher risk-taking tendency than females. Altered neural substrates associated with risky decision-making exist in IGD males but not in IGD females. Conclusions: The present findings fill the gap in information on the behavioral and neural substrates underlying IGD among females and demonstrate that a high risk-taking tendency is a risk factor and core symptom only in IGD males but not in IGD females. It is necessary to design and adopt distinct treatments and prevention strategies for IGD in males and females.
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