Observational studyBMJ paediatrics open2022
Quantifying the intensity of adverse events with ibuprofen and oxycodone: an observational cohort study.
Observational study in BMJ paediatrics open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify the frequency and intensity of adverse events (AEs), commonly known as side effects, experienced by children receiving either ibuprofen or oxycodone for pain management following an acute fracture. Secondary objectives were to quantify functional outcome impairment and describe demographic and clinical characteristics associated with AEs.
designObservational cohort study.
settingPaediatric emergency department. PATIENTS: Patients (n=240) aged 4-16 years diagnosed with an acute fracture.
interventionPrescribed either ibuprofen (n=179) or oxycodone (n=61) for pain.
main outcome measuresFamilies were called for the first 3 days after discharge to report the presence and intensity of AEs and their child's functional outcomes (ability to eat, sleep, play or attend school).
resultsOn day 1, children using oxycodone were more likely to report any AE (χ
conclusionsOxycodone is associated with more frequent AEs overall, higher intensity gastrointestinal AEs and greater functional limitations compared with ibuprofen. Lower extremity fractures cause more functional limitations than upper extremity fractures. Clinicians should consider these differences when providing fracture pain care for children.
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