Evidence map›Paper›PMID 36053650›Full record

ArticleBMJ paediatrics open2022

Predictors of extubation success: a population-based study of neonates below a gestational age of 26 weeks.

Mari Oma Ohnstad, Hans Jørgen Stensvold, Are Hugo Pripp, Christine Raaen Tvedt, Lars-Petter Jelsness-Jørgensen, Henriette Astrup, Beate Horsberg Eriksen, Claus Klingenberg, Khalaf Mreihil, Tanja Pedersen and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in BMJ paediatrics open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07240038 (Evaluation of an Evidence Based, Bundled Intervention to Reduce Incidence of Ventilator-associated Pneumonia in Neonatal Units), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07240038 recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of an Evidence Based, Bundled Intervention to Reduce Incidence of Ventilator-associated Pneumonia in Neonatal Units (INBERNAV-Neo)

Typeobservational_patient_registrySponsorBiobizkaia Health Research InstituteRan2024 to 2026Enrolled1,500ConditionsPneumonia Ventilator Associated, Pneumonia Neonatal, Healthcare-associated InfectionsArmsMultimodal intervention to reduce the incidence of ventilator-associated pneumonia by training the health care team in specific and general evidence-based good clinical practices., Technique with a blind-protected catheter
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Predictors of extubation success for premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Accuracy of lung ultrasound in predicting successful extubation in preterm infants born ≤ 25 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mari Oma OhnstadDepartment for Postgraduate Studies, Lovisenberg Diaconal University College, Oslo, Norway mari.oma.ohnstad@ldh.no.ORCID 0000-0002-5904-1347
Hans Jørgen StensvoldDepartment of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
Are Hugo PrippOslo Centre of Biostatistics and Epidemiology, Research Support Services, Oslo, Norway.
Christine Raaen TvedtDepartment for Postgraduate Studies, Lovisenberg Diaconal University College, Oslo, Norway.
Lars-Petter Jelsness-JørgensenDepartment for Postgraduate Studies, Lovisenberg Diaconal University College, Oslo, Norway.
Henriette AstrupDepartment of Pediatric and Adolescent Medicine, Sorlandet Hospital Trust, Kristiansand, Norway.
Beate Horsberg EriksenDepartment of Paediatrics, Møre og Romsdal Hospital Trust, Alesund, Norway.
Claus KlingenbergFaculty of Health Sciences, University of Tromsø, Tromso, Norway.
Khalaf MreihilDepartment of Pediatric and Adolescent Medicine, Akershus University Hospital, Lorenskog, Norway.
Tanja PedersenNeonatal Intensive Care Unit, Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
Siren RettedalDepartment of Paediatrics, Stavanger University Hospital, Stavanger, Norway.ORCID 0000-0002-0462-0659
Terje Reidar SelbergDepartment of Pediatric and Adolescent Medicine, Ostfold County Hospital, Gralum, Norway.
Rønnaug SolbergDepartment of Paediatrics, Vestfold Hospital Trust, Tonsberg, Norway.
Ragnhild StøenDepartment of Paediatrics, St Olavs Hospital Trondheim University Hospital, Trondheim, Norway.
Arild E RønnestadInstitute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
Norwegian Neonatal Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to investigate first extubation attempts among extremely premature (EP) infants and to explore factors that may increase the quality of clinical judgement of extubation readiness. DESIGN AND

methodA population-based study was conducted to explore first extubation attempts for EP infants born before a gestational age (GA) of 26 weeks in Norway between 1 January 2013 and 31 December 2018. Eligible infants were identified via the Norwegian Neonatal Network database. The primary outcome was successful extubation, defined as no reintubation within 72 hours after extubation.

resultsAmong 482 eligible infants, 316 first extubation attempts were identified. Overall, 173 (55%) infants were successfully extubated, whereas the first attempt failed in 143 (45%) infants. A total of 261 (83%) infants were extubated from conventional ventilation (CV), and 55 (17%) infants were extubated from high-frequency oscillatory ventilation (HFOV). In extubation from CV, pre-extubation fraction of inspired oxygen (FiO

conclusionsThe correct timing of extubation in EP infants is important. In this national cohort, 55% of the first extubation attempts were successful. Our results suggest that additional emphasis on oxygen requirement, sex and general condition at birth may further increase extubation success when clinicians are about to extubate EP infants for the first time.

Indexed as

Airway ExtubationHigh-Frequency VentilationFemaleGestational AgeHumansInfantInfant, Extremely PrematureInfant, NewbornOxygenOxygendata collectionneonatology

Identifiers

PMID36053650
PMCPMC9367191

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.