Evidence map›Paper›PMID 36053647›Full record

ArticleBMJ paediatrics open2022

SARS-CoV-2 tests, confirmed infections and COVID-19-related hospital admissions in children and young people: birth cohort study.

Pia Hardelid, Graziella Favarato, Linda Wijlaars, Lynda Fenton, Jim McMenamin, Tom Clemens, Chris Dibben, Ai Milojevic, Alison Macfarlane, Jonathon Taylor and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Pia HardelidPopulation, Policy & Practice Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK p.hardelid@ucl.ac.uk.ORCID 0000-0002-0154-1306
Graziella FavaratoPopulation, Policy & Practice Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.
Linda WijlaarsPopulation, Policy & Practice Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.
Lynda FentonClinical and Public Health Intelligence Team, Public Health Scotland, Edinburgh, UK.
Jim McMenaminRespiratory Infection Team, Public Health Scotland, Edinburgh, UK.
Tom ClemensSchool of Geosciences, The University of Edinburgh, Edinburgh, UK.
Chris DibbenSchool of Geosciences, The University of Edinburgh, Edinburgh, UK.
Ai MilojevicDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Alison MacfarlaneDepartment of Midwifery and Radiography, City University of London, London, UK.
Jonathon TaylorFaculty of Built Environment, Tampere University, Tampere, Finland.
Steven CunninghamCentre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
Rachael WoodClinical and Public Health Intelligence Team, Public Health Scotland, Edinburgh, UK.
Great Ormond Street Hospital · GBPublic Health Scotland · GBUniversity of Edinburgh · GBCentre for Inflammation Research · GBCity, University of London · GBLondon School of Hygiene & Tropical Medicine · GBTampere University · FI

Funding

Medical Research Council MR/T016558/1
6 · The paper itself

Abstract

backgroundThere have been no population-based studies of SARS-CoV-2 testing, PCR-confirmed infections and COVID-19-related hospital admissions across the full paediatric age range. We examine the epidemiology of SARS-CoV-2 in children and young people (CYP) aged <23 years.

methodsWe used a birth cohort of all children born in Scotland since 1997, constructed via linkage between vital statistics, hospital records and SARS-CoV-2 surveillance data. We calculated risks of tests and PCR-confirmed infections per 1000 CYP-years between August and December 2020, and COVID-19-related hospital admissions per 100 000 CYP-years between February and December 2020. We used Poisson and Cox proportional hazards regression models to determine risk factors.

resultsAmong the 1 226 855 CYP in the cohort, there were 378 402 tests (a rate of 770.8/1000 CYP-years (95% CI 768.4 to 773.3)), 19 005 PCR-confirmed infections (179.4/1000 CYP-years (176.9 to 182.0)) and 346 admissions (29.4/100 000 CYP-years (26.3 to 32.8)). Infants had the highest COVID-19-related admission rates. The presence of chronic conditions, particularly multiple types of conditions, was strongly associated with COVID-19-related admissions across all ages. Overall, 49% of admitted CYP had at least one chronic condition recorded.

conclusionsInfants and CYP with chronic conditions are at highest risk of admission with COVID-19. Half of admitted CYP had chronic conditions. Studies examining COVID-19 vaccine effectiveness among children with chronic conditions and whether maternal vaccine during pregnancy prevents COVID-19 admissions in infants are urgently needed.

Indexed as

COVID-19SARS-CoV-2AdolescentBirth CohortChildChronic DiseaseCohort StudiesCOVID-19 TestingCOVID-19 VaccinesFemaleHospitalsHumansInfantPregnancyCOVID-19 VaccinesCOVID-19epidemiology

Identifiers

PMID36053647
PMCPMC9437731
OpenAlexW4293457173

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.