Evidence map›Paper›PMID 36053618›Full record

ArticleBMJ paediatrics open2022

Gastrostomy and congenital anomalies: a European population-based study.

Ester Garne, Joachim Tan, Maria Loane, Silvia Baldacci, Elisa Ballardini, Joanne Brigden, Clara Cavero-Carbonell, Laura García-Villodre, Mika Gissler, Joanne Given and 10 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 7 countries.

Ester GarneDepartment of Paediatrics and Adolescent Medicine, Lillebaelt Hospital-University Hospital of Southern Denmark, Kolding, Denmark egarne@dadlnet.dk.ORCID 0000-0003-0430-2594
Joachim TanPopulation Health Research Institute, St George's, University of London, London, UK.
Maria LoaneCentre for Maternal, Fetal and Infant Research, INHR, Ulster University, Newtownabbey, UK.
Silvia BaldacciUnit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, Pisa, Italy.ORCID 0000-0002-7626-1202
Elisa BallardiniNeonatal Intensive Care Unit, Paediatric Section, IMER Registry (Emilia Romagna Registry of Birth Defects), Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Joanne BrigdenPopulation Health Research Institute, St George's, University of London, London, UK.
Clara Cavero-CarbonellRare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
Laura García-VillodreRare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
Mika GisslerDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Joanne GivenCentre for Maternal, Fetal and Infant Research, INHR, Ulster University, Newtownabbey, UK.
Anna HeinoKnowledge Brokers, Finnish Institute for Health and Welfare, Helsinki, Finland.
Sue JordanFaculty of Medicine, Health and Life Science, Swansea University, Swansea, Wales, UK.
Elizabeth LimbPopulation Health Research Institute, St George's, University of London, London, UK.
Amanda Julie NevilleAzienda Ospedaliero-Universitaria di Ferrara, Registro IMER, Ferrara, Italy.
Anke RissmannMalformation Monitoring Centre Saxony-Anhalt, Medical Faculty Otto-von-Guericke University, Magdeburg, Germany.ORCID 0000-0002-9437-2790
Michele SantoroUnit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, Pisa, Italy.
Leuan ScanlonFaculty of Medicine, Health and Life Science, Swansea University, Swansea, Wales, UK.
Stine Kjaer UrhojDepartment of Paediatrics and Adolescent Medicine, Lillebaelt Hospital-University Hospital of Southern Denmark, Kolding, Denmark.ORCID 0000-0002-2069-9723
Diana G WellesleyWessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK.
Joan MorrisPopulation Health Research Institute, St George's, University of London, London, UK.ORCID 0000-0002-7164-612X
St George's, University of London · GBFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESIstituto di Fisiologia Clinica · ITSwansea University · GBUniversity of Ulster · GBArcispedale Sant'Anna · ITFinnish Institute for Health and Welfare · FIKarolinska Institutet · SELillebaelt Hospital · DKOtto-von-Guericke-Universität Magdeburg · DEPrincess Anne Hospital · GBUniversity of Copenhagen · DKUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report and compare the proportion of children with and without congenital anomalies undergoing gastrostomy for tube feeding in their first 5 years.

methodsA European, population-based data-linkage cohort study (EUROlinkCAT). Children up to 5 years of age registered in nine EUROCAT registries (national and regional) in six countries and children without congenital anomalies (reference children) living in the same geographical areas were included. Data on hospitalisation and surgical procedures for all children were obtained by electronic linkage to hospital databases.

resultsThe study included 91 504 EUROCAT children and 1 960 272 reference children. Overall, 1200 (1.3%, 95% CI 1.2% to 1.6%) EUROCAT children and 374 (0.016%, 95% CI 0.009% to 0.026%) reference children had a surgical code for gastrostomy within the first 5 years of life. There were geographical variations across Europe with higher rates in Northern Europe compared with Southern Europe. Around one in four children with Cornelia de Lange syndrome and Wolf-Hirschhorn syndrome had a gastrostomy. Among children with structural anomalies, those with oesophageal atresia had the highest proportion of gastrostomy (15.9%).

conclusionsThis study including almost 2 million reference children in Europe found that only 0.016% of these children had a surgery code for gastrostomy before age 5 years. The children with congenital anomalies were on average 80 times more likely to need a gastrostomy before age 5 years than children without congenital anomalies. More than two-thirds of gastrostomy procedures performed within the first 5 years of life were in children with congenital anomalies.

Indexed as

Esophageal AtresiaGastrostomyCohort StudiesDatabases, FactualHumansRegistriesepidemiology

Identifiers

PMID36053618
PMCPMC9234789
OpenAlexW4283374109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.