Evidence map›Paper›PMID 36053504›Full record

Trial reportThe New England journal of medicine2022

Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI.

Bon-Kwon Koo, Xinyang Hu, Jeehoon Kang, Jinlong Zhang, Jun Jiang, Joo-Yong Hahn, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Weon Kim and 19 more

4 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 68 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 6 pooled it
28.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06863545 narecruitingstarted 2025, after this paper: background citation

Further Lipid-Lowering With PCSK9 Inhibitors for Cardiovascular Outcomes in High-Risk Coronary Plaques Assessed by CT Angiography

Ran2025Enrolled3,596Registered outcomes11Posted comparisons0ConditionsCardiovascular Events, Coronary Artery Disease, CT Angiography, PCSK9ArmsPCSK9 inhibitors and background lipid-modifying therapy, Standard lipid-modifying therapy
PMID 30403574PMID 28304224PMID 12800406PMID 27846344PMID 29322167PMID 30145934PMID 30678759PMID 31097161PMID 35368058PMID 36222756PMID 37471501PMID 37647074other papers from this trial
Open the trial in the graph
NCT02673424 naunknown statusnot on this map

Comparison of Clinical Outcomes Between Imaging and Physiology-guided Intervention Strategy in Patients With Intermediate Stenosis: Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis (FLAVOUR)

TypeinterventionalSponsorSeoul National University HospitalRan2016 to 2025Enrolled1,700ConditionsStable AnginaArmsFFR-guided stenting, IVUS-guided stenting
NCT06218485 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Fractional Flow Reserve-Guided Strategy Versus Intravascular Ultrasound-Guided Stent Implantation After Angiography-Derived Fractional Flow Reserve-based Decision-Making (The FLAVOUR III Trial)

TypeinterventionalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2024 to 2031Enrolled1,942ConditionsCoronary Artery DiseaseArmsIntravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making, Fractional flow reserve-guided PCI strategy
NCT07577518 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Percutaneous Intervention Versus Optimal Medical Therapy in Chronic Coronary Syndrome (PIVOT) Trial

TypeinterventionalSponsorSeoul National University HospitalRan2026 to 2034Enrolled2,301ConditionsChronic Coronary SyndromeArmspercutaneous coronary intervention, Guideline-directed Optimal Medical treatment, Carvedilol Sustained-Release (SR) (Nested RCT subset), Carvedilol Immediate-Release (IR) (Nested RCT subset)
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 6 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  10. Fractional flow reserve- and intravascular ultrasound-guided strategies for intermediate coronary stenosis and low lesion complexity in patients with or without diabetes: a post hoc analysis of the randomised FLAVOUR trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Trial
  11. Article
  12. Review
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  14. Review
  15. A Case of the Uncommon Cause of Chronic Coronary Syndrome: Coronary Fistula and Coronary Stenosis, Which One to Intervene?The International journal of angiology : official publication of the International College of Angiology, Inc · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 9 institutions in 2 countries.

Bon-Kwon KooFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Xinyang HuFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Jeehoon KangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Jinlong ZhangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0003-4326-5087
Jun JiangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Joo-Yong HahnFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0002-4412-377X
Chang-Wook NamFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Joon-Hyung DohFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Bong-Ki LeeFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Weon KimFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Jinyu HuangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Fan JiangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Hao ZhouFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Peng ChenFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Lijiang TangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Wenbing JiangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Xiaomin ChenFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Wenming HeFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0002-6018-437X
Sung-Gyun AhnFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0002-1528-2739
Myeong-Ho YoonFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Ung KimFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Joo-Myung LeeFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0002-2178-4014
Doyeon HwangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
You-Jeong KiFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0003-0102-2810
Eun-Seok ShinFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.ORCID 0000-0002-9169-6968
Hyo-Soo KimFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Seung-Jea TahkFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
Jian'an WangFrom Seoul National University Hospital (B.-K.K., J.K., D.H., H.-S.K.), Samsung Medical Center (J.-Y.H., J.-M.L.), and Kyung Hee University Hospital (W.K.), Seoul, Keimyung University Dongsan Medical Center (C.-W.N.) and Yeungnam University Medical Center (U.K.), Daegu, Inje University Ilsan Paik Hospital, Goyang (J.-H.D.), Kangwon National University Hospital, Chuncheon (B.-K.L.), Wonju Severance Christian Hospital, Wonju (S.-G.A.), Ajou University Hospital, Suwon (M.-H.Y., S.-J.T.), Uijeongbu Eulji Medical Center, Uijeongbu (Y-.J.K.), and Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (E.-S.S.) - all in South Korea; the Second Affiliated Hospital, Zhejiang University School of Medicine (X.H., J.Z., J.J., J.W.), Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine (J.H.), Hangzhou Normal University Affiliated Hospital (F.J.), and Zhejiang Hospital (L.T.), Hangzhou, the First Affiliated Hospital of Wenzhou Medical University (H.Z.), the Second Affiliated Hospital of Wenzhou Medical University (P.C.), and the Third Clinical Institute Affiliated to Wenzhou Medical University (W.J.), Wenzhou, and Ningbo First Hospital (X.C.) and the Affiliated Hospital of the Medical School of Ningbo University (W.H.), Ningbo - all in China.
FLAVOUR Investigators
Kangwon National University Hospital · KRSeoul National University Hospital · KRWenzhou Medical University · CNAjou University Hospital · KRSamsung Medical Center · KRAffiliated Hospital of Hangzhou Normal University · CNInje University Ilsan Paik Hospital · KRUlsan College · KRWonju Severance Christian Hospital · KR

Funding

Boston Scientific Corporation 1602-134-744
6 · The paper itself

Abstract

backgroundIn patients with coronary artery disease who are being evaluated for percutaneous coronary intervention (PCI), procedures can be guided by fractional flow reserve (FFR) or intravascular ultrasonography (IVUS) for decision making regarding revascularization and stent implantation. However, the differences in clinical outcomes when only one method is used for both purposes are unclear.

methodsWe randomly assigned 1682 patients who were being evaluated for PCI for the treatment of intermediate stenosis (40 to 70% occlusion by visual estimation on coronary angiography) in a 1:1 ratio to undergo either an FFR-guided or IVUS-guided procedure. FFR or IVUS was to be used to determine whether to perform PCI and to assess PCI success. In the FFR group, PCI was to be performed if the FFR was 0.80 or less. In the IVUS group, the criteria for PCI were a minimal lumen area measuring either 3 mm

resultsThe frequency of PCI was 44.4% among patients in the FFR group and 65.3% among those in the IVUS group. At 24 months, a primary-outcome event had occurred in 8.1% of the patients in the FFR group and in 8.5% of those in the IVUS group (absolute difference, -0.4 percentage points; upper boundary of the one-sided 97.5% confidence interval, 2.2 percentage points; P = 0.01 for noninferiority). Patient-reported outcomes as reported on the Seattle Angina Questionnaire were similar in the two groups.

conclusionsIn patients with intermediate stenosis who were being evaluated for PCI, FFR guidance was noninferior to IVUS guidance with respect to the composite primary outcome of death, myocardial infarction, or revascularization at 24 months. (Funded by Boston Scientific; FLAVOUR ClinicalTrials.gov number, NCT02673424.).

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialMyocardial InfarctionPercutaneous Coronary InterventionUltrasonography, InterventionalConstriction, PathologicCoronary AngiographyHumansTreatment Outcome

Identifiers

PMID36053504
OpenAlexW4293842419

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