ArticlePediatric nephrology (Berlin, Germany)2023
Blood pressure and kidney function in neonates and young infants with intrauterine growth restriction.
Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Investigating ethylene oxide exposure and its associations with kidney indicators and lipid profiles: the mediating effect of HDL in NHANES 2013-2020.Frontiers in physiology · 2025Article
- The impact of intrauterine growth restriction and prematurity on nephron endowment.Nature reviews. Nephrology · 2023Review
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundIntrauterine growth restriction (IUGR) has been associated with changes in kidney anatomy, nephrogenesis and the vascular system, resulting in secondary arterial hypertension and kidney damage in adulthood. Here, we compare routine clinical and metabolic parameters between IUGR and non-IUGR study participants in the neonatal and early infant period.
methodsA total of 39 IUGR and 60 non-IUGR neonates were included during an 18-month study period. We compared blood pressure, serum creatinine (SCr), urea nitrogen (BUN), urinary albumin, α-1-microglobulin, transferrin, immunoglobulin G and total protein excretion in spontaneous urine normalized by urine creatinine level during the hospital stay.
resultsThere were no significant differences in mean values of blood pressure and urinary protein excretion between cases and controls. SCr and BUN levels were lower in the IUGR group compared to the non-IUGR group.
conclusionsThe lower levels of SCr and BUN may be attributed to lower liver and muscle mass in IUGR neonates and young infants. Biomarkers currently used in routine clinical care do not allow early postnatal prediction of higher blood pressure or worse kidney function due to IUGR, so further studies are needed. A higher resolution version of the Graphical abstract is available as Supplementary information.
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